Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/5492
Title: | Neurobiological Pathways Between Chronic Stress and Depression: Dysregulated Adaptive Mechanisms? | Contributor(s): | Sharpley, Christopher (author) | Publication Date: | 2009 | Handle Link: | https://hdl.handle.net/1959.11/5492 | Abstract: | Stress-related diseases have been predicted to become major contributors to the Global Disease Burden within the next 20 years. Of these, depression is one of the principal identifiable sources of concern for public mental health, and has been hypothesized to be an outcome of prolonged stress. Examination of the hyper-responsiveness of the Hypothalamic-Pituitary-Adrenal axis, consequent elevated serum cortisol, plus the effects of this upon brain structure and function, provides a model for understanding how chronic stress may be a causal vector in the development of depression. Evidence from studies of the effectiveness of antidepressants aimed at reducing cortisol within depressed patients supports this model and suggests avenues for future research and treatment of stress-induced depression. | Publication Type: | Journal Article | Source of Publication: | Clinical Medicine: Psychiatry, v.2, p. 33-45 | Publisher: | Libertas Academica Ltd | Place of Publication: | New Zealand | ISSN: | 1179-5573 | Fields of Research (FoR) 2008: | 110319 Psychiatry (incl Psychotherapy) | Socio-Economic Objective (SEO) 2008: | 920111 Nervous System and Disorders | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal | Publisher/associated links: | http://www.la-press.com/neurobiological-pathways-between-chronic-stress-and-depression-dysregu-article-a1773 |
---|---|
Appears in Collections: | Journal Article School of Science and Technology |
Files in This Item:
File | Description | Size | Format |
---|
Page view(s)
1,282
checked on Jun 23, 2024
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.