Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/53697
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dc.contributor.authorYu, Sung Jen
dc.contributor.authorBajagai, Yadav Sen
dc.contributor.authorPetranyi, Friedrichen
dc.contributor.authorde las Heras-Saldana, Saraen
dc.contributor.authorVan, Thi Thu Haoen
dc.contributor.authorStanley, Draganaen
dc.date.accessioned2022-11-22T03:23:01Z-
dc.date.available2022-11-22T03:23:01Z-
dc.date.issued2022-10-18-
dc.identifier.citationAntibiotics, 11(10), p. 1-14en
dc.identifier.issn2079-6382en
dc.identifier.urihttps://hdl.handle.net/1959.11/53697-
dc.description.abstractPoultry production is among the most challenging industries for pathogen control. High animal density and abundance of faecal material demand strict biosecurity measures and continual vigilance in monitoring animal health parameters. Despite this vigilance, dealing with disease outbreaks is a part of farmers' routines. Phytogenic feed additives comprised of herbs, spices, essential oils, and oleoresins have potent antimicrobial and anti-inflammatory actions. Related studies are gaining substantial interest in human and animal health worldwide. In this study, a commercial blend phytogenic feed additive was supplemented to layers in an industrial free-range production system with 20,000 birds in both control and treatment groups. At the end of the trial, the ileum tissue was sampled for RNAseq transcriptomic analysis to study the host reaction to the supplement. Phytogenic supplement significantly inhibited four cholesterol-related pathways and reduced the Arteriosclerosis disease category towards improved cardiovascular health. The supplemented birds exhibited reduced disease susceptibility for 26 cancer categories with <i>p</i>-values in the range from 5.23 × 10<sup>−4</sup> to 1.02 × 10<sup>−25</sup>. Major metabolic shifts in Lipid metabolism in combination with Carbohydrate metabolism have resulted in a decrease in the Obesity category, altering the ratio of fat and carbohydrate metabolism toward lower fat storage.en
dc.languageenen
dc.publisherMDPI AGen
dc.relation.ispartofAntibioticsen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePhytogenic Blend Improves Intestinal Health and Reduces Obesity, Diabetes, Cholesterol and Cancers: A Path toward Customised Supplementationen
dc.typeJournal Articleen
dc.identifier.doi10.3390/antibiotics11101428en
dc.identifier.pmid36290086en
dcterms.accessRightsUNE Greenen
local.contributor.firstnameSung Jen
local.contributor.firstnameYadav Sen
local.contributor.firstnameFriedrichen
local.contributor.firstnameSaraen
local.contributor.firstnameThi Thu Haoen
local.contributor.firstnameDraganaen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailsdelash2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeSwitzerlanden
local.identifier.runningnumber1428en
local.format.startpage1en
local.format.endpage14en
local.identifier.scopusid85140437933en
local.peerreviewedYesen
local.identifier.volume11en
local.identifier.issue10en
local.title.subtitleA Path toward Customised Supplementationen
local.access.fulltextYesen
local.contributor.lastnameYuen
local.contributor.lastnameBajagaien
local.contributor.lastnamePetranyien
local.contributor.lastnamede las Heras-Saldanaen
local.contributor.lastnameVanen
local.contributor.lastnameStanleyen
dc.identifier.staffune-id:sdelash2en
local.profile.orcid0000-0002-8665-6160en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/53697en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitlePhytogenic Blend Improves Intestinal Health and Reduces Obesity, Diabetes, Cholesterol and Cancersen
local.relation.fundingsourcenoteThis research was funded by the Central Queensland University Merit Grant scheme under the project funding number RSH/4200.en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorYu, Sung Jen
local.search.authorBajagai, Yadav Sen
local.search.authorPetranyi, Friedrichen
local.search.authorde las Heras-Saldana, Saraen
local.search.authorVan, Thi Thu Haoen
local.search.authorStanley, Draganaen
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/ac27794a-a3d3-4ec5-b51c-8149188c7211en
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.identifier.wosid000872021500001en
local.year.published2022en
local.fileurl.openhttps://rune.une.edu.au/web/retrieve/ac27794a-a3d3-4ec5-b51c-8149188c7211en
local.fileurl.openpublishedhttps://rune.une.edu.au/web/retrieve/ac27794a-a3d3-4ec5-b51c-8149188c7211en
local.subject.for2020310904 Animal diet and nutritionen
local.subject.seo2020100411 Poultryen
Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
Journal Article
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This item is licensed under a Creative Commons License Creative Commons