Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/52108
Title: Anti-streptococcal antibody and T-cell interactions with vascular endothelial cells initiate the development of rheumatic carditis
Contributor(s): Sikder, Suchandan  (author); Rush, Catherine M (author); Govan, Brenda L (author); Lim, Md A (author); Ketheesan, Natkunam  (author)orcid 
Publication Date: 2020-02
Early Online Version: 2019-10-16
Open Access: Yes
DOI: 10.1002/JLB.4MA0919-096RROpen Access Link
Handle Link: https://hdl.handle.net/1959.11/52108
Abstract: 

The role of group A streptococcal and Streptococcus dysgalactiae subspecies equisimilis M-protein specific Abs and T-cells in endothelial cell activation was investigated using cultured rat aortic endothelial cells, and in a rat model of autoimmune valvulitis. Heat inactivated serum and mononuclear cells from streptococcal M-protein immunized rats independently induced upregulation of the endothelial cell adhesion molecules, vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1 in cultured cells. We also observed T-cell migration across endothelial cell monolayers incubated with serum from M-protein-immunized rats. Furthermore, we observed VCAM-1 and ICAM-1 expression in the myocardium of rats injected with M-protein compared to control animals. These observations support the contention that initial interactions between streptococcal M-protein specific Abs and/or T-cells with the heart endothelium lead to endothelial cell activation followed by transmigration of M-protein specific T-cells into heart tissue leading to an inflammatory process that leads to carditis in rheumatic fever and rheumatic heart disease.

Publication Type: Journal Article
Grant Details: NHMRC/1026753
Source of Publication: Journal of Leukocyte Biology, 107(2), p. 263-271
Publisher: Oxford University Press
Place of Publication: United Kingdom
ISSN: 1938-3673
0741-5400
Fields of Research (FoR) 2020: 320211 Infectious diseases
320701 Medical bacteriology
Socio-Economic Objective (SEO) 2020: 200104 Prevention of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Description: This article includes concepts first presented at Lorne Infection & Immunity Conference 2019.
Appears in Collections:Journal Article
School of Science and Technology

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