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https://hdl.handle.net/1959.11/52086
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DC Field | Value | Language |
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dc.contributor.author | Tully, Phillip J | en |
dc.contributor.author | Peters, Ruth | en |
dc.contributor.author | Pérès, Karine | en |
dc.contributor.author | Anstey, Kaarin J | en |
dc.contributor.author | Tzourio, Christophe | en |
dc.date.accessioned | 2022-05-11T04:40:43Z | - |
dc.date.available | 2022-05-11T04:40:43Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.citation | International Psychogeriatrics, 30(9), p. 1345-1354 | en |
dc.identifier.issn | 1741-203X | en |
dc.identifier.issn | 1041-6102 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/52086 | - |
dc.description.abstract | <p><b>Background:</b> Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive decline in an elderly population with hypertension.</p><p><b>Methods:</b> Prospective study of 296 persons treated with SSRI and antihypertensive drugs. Baseline and two year clinic assessments were used to categorize participants as users of SSRI + CCB (<i>n</i> = 53) or users of SSRI + other antihypertensives (<i>n</i> = 243). Clinic visits were performed up to four times in a ten-year period to assess depression and cognitive function.</p><p><b>Results:</b> The sample mean age was 75.2 ± 5.47 years and 78% of participants were female. At two year follow-up there was a significant group by time interaction showing lower Center for Epidemiological Studies-Depression (CESD) scores in the SSRI + CCB group, F(1,291) = 4.13, p = 0.043, <i>η</i><sup>2</sup><sub>p</sub> = 0.014. Over ten-years follow-up, SSRI + CCB use was associated with improved general cognitive function (Mini-Mental State Examination: <i>β</i> = 0.97; 95% CI 0.14 to 1.81, p = 0.023) and immediate visual memory (Boston Visual Retention Test: <i>β</i> = 0.69; 95% CI 0.06 to 1.32, p = 0.033).</p><p><b>Conclusion:</b> The findings provide general population evidence that SSRI augmentation with CCB may improve depression and cognitive function.</p> | en |
dc.language | en | en |
dc.publisher | Cambridge University Press | en |
dc.relation.ispartof | International Psychogeriatrics | en |
dc.title | Effect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1017/S1041610217002903 | en |
local.contributor.firstname | Phillip J | en |
local.contributor.firstname | Ruth | en |
local.contributor.firstname | Karine | en |
local.contributor.firstname | Kaarin J | en |
local.contributor.firstname | Christophe | en |
local.profile.school | School of Psychology | en |
local.profile.email | ptully2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 1345 | en |
local.format.endpage | 1354 | en |
local.identifier.scopusid | 85044250113 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 30 | en |
local.identifier.issue | 9 | en |
local.title.subtitle | three city cohort study | en |
local.contributor.lastname | Tully | en |
local.contributor.lastname | Peters | en |
local.contributor.lastname | Pérès | en |
local.contributor.lastname | Anstey | en |
local.contributor.lastname | Tzourio | en |
dc.identifier.staff | une-id:ptully2 | en |
local.profile.orcid | 0000-0003-2807-1313 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/52086 | en |
local.date.onlineversion | 2018-03-27 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Effect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension | en |
local.relation.fundingsourcenote | The Three-City (3C) Study is conducted under a partnership agreement between the Institut National de la Sante et de la Recherche Medicale (INSERM), the Victor Segalen-Bordeaux II University, and Sanofi-Aventis. The Fondation pour la Recherche Medicale funded the preparation and initiation of the study. The Fondation Plan Alzheimer partly funded the follow-up of the study. The 3C Study is also supported by the Caisse Nationale Maladie des Travailleurs Salaries, Direction Generale de la Sante, MGEN, Institut de la Longevite, Conseils Regionaux of Aquitaine and Bourgogne, Fondation de France, la Caisse Nationale de Solidarité et d’Autonomie (CNSA) and the Ministry of Research-INSERM Programme “Cohortes et collections de donnees biologiques.” The 3C Study supports are listed on the Study website (www.three-city-study.com). | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Tully, Phillip J | en |
local.search.author | Peters, Ruth | en |
local.search.author | Pérès, Karine | en |
local.search.author | Anstey, Kaarin J | en |
local.search.author | Tzourio, Christophe | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.year.available | 2018 | - |
local.year.published | 2018 | - |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/e4d9adb7-4132-46ec-bcd7-75110df02aaf | en |
local.subject.for2020 | 520304 Health psychology | en |
local.subject.seo2020 | 200502 Health related to ageing | en |
Appears in Collections: | Journal Article School of Psychology |
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