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https://hdl.handle.net/1959.11/51840
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DC Field | Value | Language |
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dc.contributor.author | Tully, Phillip J | en |
dc.contributor.author | Debette, Stephanie | en |
dc.contributor.author | Mazoyer, Bernard | en |
dc.contributor.author | Tzourio, Christophe | en |
dc.date.accessioned | 2022-04-29T03:43:38Z | - |
dc.date.available | 2022-04-29T03:43:38Z | - |
dc.date.issued | 2017-12-01 | - |
dc.identifier.citation | American Journal of Geriatric Psychiatry, 25(12), p. 1311-1321 | en |
dc.identifier.issn | 1545-7214 | en |
dc.identifier.issn | 1064-7481 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/51840 | - |
dc.description.abstract | <p>Objective:</p><p> Evidence is mixed as to whether periventricular or deep white matter hyperintensities (WMHs) increase the risk for depressive symptoms, partly because of heterogeneity in depression measurement, short follow-up, and confounding by prodromal dementia. The study objective was to evaluate WMH volume in relation to discrete depressive symptoms over 10 years, stratifying by incident depression and dementia.</p><p> Methods: </p><p>In this prospective longitudinal cohort study of a representative population sample from Dijon, France, 1,440 participants aged 65-80 years (median age: 72 years; 59.5% women) without depression, dementia, or stroke at baseline were studied. Baseline T2-weighted images were obtained in a 1.5-T scanner to quantify WMHs (log cm<sup>3</sup>). Clinic visits were performed up to five times in a 10-year period to assess incident neurologic diseases and comorbidities. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression Scale and converted to factor z scores, representing somatic symptoms, depressed affect, low positive affect, and interpersonal problems.</p><p> Results: </p><p>Periventricular WMH volume was uniquely associated with low positive affect among incident depression cases (β = 0.15; 95% confidence interval [CI]: 0.02-0.29; p = 0.026). Deep WMH volume was uniquely associated with depressed affect among incident dementia cases (β = 0.36; 95% CI: 0.05-0.68; p = 0.025). WMH volume (periventricular, deep, and total) was associated with interpersonal problems among persons who developed dementia with depression.</p><p></p><p> Conclusion:</p><p> </p><p>The findings highlight that regional WMH volumes and specific depressive symptoms have clinical and prognostic relevance to help differentiate between persons at risk for depression and dementia.</p> | en |
dc.language | en | en |
dc.publisher | Elsevier Inc | en |
dc.relation.ispartof | American Journal of Geriatric Psychiatry | en |
dc.title | White Matter Lesions are Associated with Specific Depressive Symptom Trajectories among Incident Depression and Dementia Populations: Three-City Dijon MRI Study | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1016/j.jagp.2017.06.003 | en |
dc.identifier.pmid | 28688824 | en |
local.contributor.firstname | Phillip J | en |
local.contributor.firstname | Stephanie | en |
local.contributor.firstname | Bernard | en |
local.contributor.firstname | Christophe | en |
local.profile.school | School of Psychology | en |
local.profile.email | ptully2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United States of America | en |
local.format.startpage | 1311 | en |
local.format.endpage | 1321 | en |
local.identifier.scopusid | 85021826685 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 25 | en |
local.identifier.issue | 12 | en |
local.title.subtitle | Three-City Dijon MRI Study | en |
local.contributor.lastname | Tully | en |
local.contributor.lastname | Debette | en |
local.contributor.lastname | Mazoyer | en |
local.contributor.lastname | Tzourio | en |
dc.identifier.staff | une-id:ptully2 | en |
local.profile.orcid | 0000-0003-2807-1313 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/51840 | en |
local.date.onlineversion | 2017-06-06 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | White Matter Lesions are Associated with Specific Depressive Symptom Trajectories among Incident Depression and Dementia Populations | en |
local.relation.fundingsourcenote | Institut National de la Sante et de la Recherche Medicale (INSERM), the Victor SegalenBordeaux II University, and Sanofi-Aventis | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Tully, Phillip J | en |
local.search.author | Debette, Stephanie | en |
local.search.author | Mazoyer, Bernard | en |
local.search.author | Tzourio, Christophe | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.identifier.wosid | 000415130200004 | en |
local.year.available | 2017 | en |
local.year.published | 2017 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/878b9561-451b-499e-92bb-c5087729fea9 | en |
local.subject.for2020 | 520302 Clinical psychology | en |
local.subject.seo2020 | 200409 Mental health | en |
Appears in Collections: | Journal Article School of Psychology |
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