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https://hdl.handle.net/1959.11/48215
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DC Field | Value | Language |
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dc.contributor.author | Diffenderfer, Margaret R | en |
dc.contributor.author | Lamon-Fava, Stefania | en |
dc.contributor.author | Marcovina, Santica M | en |
dc.contributor.author | Barrett, P Hugh R | en |
dc.contributor.author | Lel, Julian | en |
dc.contributor.author | Dolnikowski, Gregory G | en |
dc.contributor.author | Berglund, Lars | en |
dc.contributor.author | Schaefer, Ernst J | en |
dc.date.accessioned | 2022-03-09T23:01:58Z | - |
dc.date.available | 2022-03-09T23:01:58Z | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | Metabolism, 65(4), p. 381-390 | en |
dc.identifier.issn | 1532-8600 | en |
dc.identifier.issn | 0026-0495 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/48215 | - |
dc.description.abstract | <p>Objectives</p> <p>Lipoprotein(a) [Lp(a)] is mainly similar in composition to LDL, but differs in having apolipoprotein (apo) (a) covalently linked to apoB-100. Our purpose was to examine the individual metabolism of apo(a) and apoB-100 within plasma Lp(a).</p> <p>Materials and Methods</p> <p>The kinetics of apo(a) and apoB-100 in plasma Lp(a) were assessed in four men with dyslipidemia [Lp(a) concentration: 8.9–124.7 nmol/L]. All subjects received a primed constant infusion of [5,5,5-2H3] L-leucine while in the constantly fed state. Lp(a) was immunoprecipitated directly from whole plasma; apo(a) and apoB-100 were separated by gel electrophoresis; and isotopic enrichment was determined by gas chromatography/mass spectrometry.</p> <p>Results</p> <p>Multicompartmental modeling analysis indicated that the median fractional catabolic rates of apo(a) and apoB-100 within Lp(a) were significantly different at 0.104 and 0.263 pools/day, respectively (P = 0.04). The median Lp(a) apo(a) production rate at 0.248 nmol/kg · day− 1 was significantly lower than that of Lp(a) apoB-100 at 0.514 nmol/kg · day− 1 (P = 0.03).</p> <p>Conclusion</p> <p>Our data indicate that apo(a) has a plasma residence time (11 days) that is more than twice as long as that of apoB-100 (4 days) within Lp(a), supporting the concept that apo(a) and apoB-100 within plasma Lp(a) are not catabolized from the bloodstream as a unit in humans in the fed state.</p> | en |
dc.language | en | en |
dc.publisher | Elsevier Inc | en |
dc.relation.ispartof | Metabolism | en |
dc.title | Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a) | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1016/j.metabol.2015.10.031 | en |
local.contributor.firstname | Margaret R | en |
local.contributor.firstname | Stefania | en |
local.contributor.firstname | Santica M | en |
local.contributor.firstname | P Hugh R | en |
local.contributor.firstname | Julian | en |
local.contributor.firstname | Gregory G | en |
local.contributor.firstname | Lars | en |
local.contributor.firstname | Ernst J | en |
local.profile.school | Faculty of Medicine and Health | en |
local.profile.email | pbarret6@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United States of America | en |
local.format.startpage | 381 | en |
local.format.endpage | 390 | en |
local.identifier.scopusid | 84960452830 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 65 | en |
local.identifier.issue | 4 | en |
local.contributor.lastname | Diffenderfer | en |
local.contributor.lastname | Lamon-Fava | en |
local.contributor.lastname | Marcovina | en |
local.contributor.lastname | Barrett | en |
local.contributor.lastname | Lel | en |
local.contributor.lastname | Dolnikowski | en |
local.contributor.lastname | Berglund | en |
local.contributor.lastname | Schaefer | en |
dc.identifier.staff | une-id:pbarret6 | en |
local.profile.orcid | 0000-0003-3223-6125 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/48215 | en |
local.date.onlineversion | 2015-11-06 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a) | en |
local.relation.fundingsourcenote | This work was supported by U.S. Department of Agriculture Research Service Contract 53-3K-06 (E.J.S.) and by Project Grant P50 HL083813-01 (E.J.S.) and Project Grant HL62705 (L.B.) from the National Institutes of Health. Additional support was provided by an investigator-initiated research grant from Abbott Laboratories, Abbott Park, IL (E.J.S). P.H.R.B. is a senior research fellow of the National Health and Medical Research Council of Australia. | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Diffenderfer, Margaret R | en |
local.search.author | Lamon-Fava, Stefania | en |
local.search.author | Marcovina, Santica M | en |
local.search.author | Barrett, P Hugh R | en |
local.search.author | Lel, Julian | en |
local.search.author | Dolnikowski, Gregory G | en |
local.search.author | Berglund, Lars | en |
local.search.author | Schaefer, Ernst J | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.year.available | 2015 | - |
local.year.published | 2016 | - |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/97aa07a3-a6b4-4c3d-8fdd-de41f307637f | en |
local.subject.for2020 | 320101 Cardiology (incl. cardiovascular diseases) | en |
local.subject.seo2020 | 200105 Treatment of human diseases and conditions | en |
Appears in Collections: | Journal Article |
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