| Title: | ω-3 Fatty Acid Ethyl Esters Diminish Postprandial Lipemia in Familial Hypercholesterolemia |
Contributor(s): | Chan, Dick C (author) ; Pang, Jing (author) ; Barrett, P Hugh R (author) ; Sullivan, David R (author); Burnett, John R (author) ; van Bockxmeer, Frank M (author); Watts, Gerald F (author) |
Publication Date: | 2016-10-01 |
Early Online Version: | 2016-08-04 |
Open Access: | Yes |
DOI: | 10.1210/jc.2016-2217 |
Handle Link: | https://hdl.handle.net/1959.11/47984 |
Abstract: | | Context:
Impaired postprandial chylomicron metabolism induces hypertriglyceridemia and may increase the risk of atherosclerotic cardiovascular disease. Omega-3 fatty acid ethyl ester (ω-3 FAEE) supplementation decreases plasma triglycerides. However, its effect on postprandial chylomicron metabolism in familial hypercholesterolemia (FH) has not yet been investigated.
Objective:
We aimed to examine the effect of ω-3 FAEE supplementation on postprandial responses in plasma triglycerides, very-low-density lipoprotein (VLDL) apolipoprotein B (apoB)-100, and apoB-48 in FH patients receiving standard cholesterol-lowering treatment.
Design, Setting, and Patients:
We carried out an 8-week open-label, randomized, crossover intervention trial to test the effect of oral supplementation with 4 g/d ω-3 FAEE (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on postprandial triglyceride, VLDL-apoB-100, and apoB-48 responses in FH patients after ingestion of an oral fat load.
Outcomes Measures:
Plasma total and incremental triglyceride, VLDL-apoB-100, and apoB-48 0- to 10-hour area under the curve (AUC).
Results:
ω-3 FAEE supplementation significantly (P < .05 in all) reduced concentrations of fasting plasma triglyceride (-20%), apoB (-8%), VLDL-apoB-100 (-26%), and apoB-48 (-36%); as well as systolic blood pressure (-6%) and diastolic blood pressure (-6%). Postprandial triglyceride and VLDL-apoB-100 total AUCs (-19% and -26%, respectively; P < .01) and incremental AUCs (-18% and -35%, respectively; P < .05), as well as postprandial apoB-48 total AUC (-30%; P < .02) were significantly reduced by ω-3 FAEE supplementation.
Conclusion:
Supplementation with ω-3 FAEEs improves postprandial lipemia in FH patients receiving standard care; this may have implications for further reducing atherosclerotic cardiovascular disease in this high-risk patient group.
Publication Type: | Journal Article |
Source of Publication: | Journal of Clinical Endocrinology and Metabolism, 101(10), p. 3732-3739 |
Publisher: | Oxford University Press |
Place of Publication: | United States of America |
ISSN: | 1945-7197
0021-972X |
Fields of Research (FoR) 2020: | 320101 Cardiology (incl. cardiovascular diseases) |
Socio-Economic Objective (SEO) 2020: | 200105 Treatment of human diseases and conditions |
Peer Reviewed: | Yes |
HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
| Appears in Collections: | Journal Article
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