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https://hdl.handle.net/1959.11/47984
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, Dick C | en |
dc.contributor.author | Pang, Jing | en |
dc.contributor.author | Barrett, P Hugh R | en |
dc.contributor.author | Sullivan, David R | en |
dc.contributor.author | Burnett, John R | en |
dc.contributor.author | van Bockxmeer, Frank M | en |
dc.contributor.author | Watts, Gerald F | en |
dc.date.accessioned | 2022-03-09T00:55:25Z | - |
dc.date.available | 2022-03-09T00:55:25Z | - |
dc.date.issued | 2016-10-01 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 101(10), p. 3732-3739 | en |
dc.identifier.issn | 1945-7197 | en |
dc.identifier.issn | 0021-972X | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/47984 | - |
dc.description.abstract | <p><b>Context:</b></p> <p>Impaired postprandial chylomicron metabolism induces hypertriglyceridemia and may increase the risk of atherosclerotic cardiovascular disease. Omega-3 fatty acid ethyl ester (ω-3 FAEE) supplementation decreases plasma triglycerides. However, its effect on postprandial chylomicron metabolism in familial hypercholesterolemia (FH) has not yet been investigated.</p> <p><b>Objective:</b></p> <p>We aimed to examine the effect of ω-3 FAEE supplementation on postprandial responses in plasma triglycerides, very-low-density lipoprotein (VLDL) apolipoprotein B (apoB)-100, and apoB-48 in FH patients receiving standard cholesterol-lowering treatment.</p> <p><b>Design, Setting, and Patients:</b></p> <p>We carried out an 8-week open-label, randomized, crossover intervention trial to test the effect of oral supplementation with 4 g/d ω-3 FAEE (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on postprandial triglyceride, VLDL-apoB-100, and apoB-48 responses in FH patients after ingestion of an oral fat load.</p> <p><b>Outcomes Measures:</b></p> <p>Plasma total and incremental triglyceride, VLDL-apoB-100, and apoB-48 0- to 10-hour area under the curve (AUC).</p> <p><b>Results:</b></p> <p>ω-3 FAEE supplementation significantly (<i>P</i> < .05 in all) reduced concentrations of fasting plasma triglyceride (-20%), apoB (-8%), VLDL-apoB-100 (-26%), and apoB-48 (-36%); as well as systolic blood pressure (-6%) and diastolic blood pressure (-6%). Postprandial triglyceride and VLDL-apoB-100 total AUCs (-19% and -26%, respectively; <i>P</i> < .01) and incremental AUCs (-18% and -35%, respectively; <i>P</i> < .05), as well as postprandial apoB-48 total AUC (-30%; <i>P</i> < .02) were significantly reduced by ω-3 FAEE supplementation.</p> <p><b>Conclusion:</b></p> <p>Supplementation with ω-3 FAEEs improves postprandial lipemia in FH patients receiving standard care; this may have implications for further reducing atherosclerotic cardiovascular disease in this high-risk patient group.</p> | en |
dc.language | en | en |
dc.publisher | Oxford University Press | en |
dc.relation.ispartof | Journal of Clinical Endocrinology and Metabolism | en |
dc.title | ω-3 Fatty Acid Ethyl Esters Diminish Postprandial Lipemia in Familial Hypercholesterolemia | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1210/jc.2016-2217 | en |
dcterms.accessRights | Bronze | en |
local.contributor.firstname | Dick C | en |
local.contributor.firstname | Jing | en |
local.contributor.firstname | P Hugh R | en |
local.contributor.firstname | David R | en |
local.contributor.firstname | John R | en |
local.contributor.firstname | Frank M | en |
local.contributor.firstname | Gerald F | en |
local.profile.school | Faculty of Medicine and Health | en |
local.profile.email | pbarret6@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United States of America | en |
local.format.startpage | 3732 | en |
local.format.endpage | 3739 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 101 | en |
local.identifier.issue | 10 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Chan | en |
local.contributor.lastname | Pang | en |
local.contributor.lastname | Barrett | en |
local.contributor.lastname | Sullivan | en |
local.contributor.lastname | Burnett | en |
local.contributor.lastname | van Bockxmeer | en |
local.contributor.lastname | Watts | en |
dc.identifier.staff | une-id:pbarret6 | en |
local.profile.orcid | 0000-0001-7658-5197 | en |
local.profile.orcid | 0000-0002-9700-6948 | en |
local.profile.orcid | 0000-0003-3223-6125 | en |
local.profile.orcid | 0000-0002-0135-6119 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/47984 | en |
local.date.onlineversion | 2016-08-04 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | ω-3 Fatty Acid Ethyl Esters Diminish Postprandial Lipemia in Familial Hypercholesterolemia | en |
local.relation.fundingsourcenote | This study was supported by grants from the National Health Medical Research Council of Australia (NHMRC). | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Chan, Dick C | en |
local.search.author | Pang, Jing | en |
local.search.author | Barrett, P Hugh R | en |
local.search.author | Sullivan, David R | en |
local.search.author | Burnett, John R | en |
local.search.author | van Bockxmeer, Frank M | en |
local.search.author | Watts, Gerald F | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.year.available | 2016 | en |
local.year.published | 2016 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/7202c763-8f99-44fc-9c3f-41b5faa03800 | en |
local.subject.for2020 | 320101 Cardiology (incl. cardiovascular diseases) | en |
local.subject.seo2020 | 200105 Treatment of human diseases and conditions | en |
Appears in Collections: | Journal Article |
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