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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/46928
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dc.contributor.authorSathkumara, Harindra Den
dc.contributor.authorHansen, Karynaen
dc.contributor.authorMiranda-Hernandez, Socorroen
dc.contributor.authorGovan, Brendaen
dc.contributor.authorRush, Catherine Men
dc.contributor.authorHenning, Larsen
dc.contributor.authorKetheesan, Natkunamen
dc.contributor.authorKupz, Andreasen
dc.date.accessioned2022-03-07T00:29:43Z-
dc.date.available2022-03-07T00:29:43Z-
dc.date.issued2020-12-16-
dc.identifier.citationAntimicrobial Agents and Chemotherapy, 65(1), p. 1-5en
dc.identifier.issn1098-6596en
dc.identifier.issn0066-4804en
dc.identifier.urihttps://hdl.handle.net/1959.11/46928-
dc.description.abstractComorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.en
dc.languageenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.ispartofAntimicrobial Agents and Chemotherapyen
dc.titleDisparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Miceen
dc.typeJournal Articleen
dc.identifier.doi10.1128/AAC.01422-20en
dc.identifier.pmid33046495en
dcterms.accessRightsBronzeen
local.contributor.firstnameHarindra Den
local.contributor.firstnameKarynaen
local.contributor.firstnameSocorroen
local.contributor.firstnameBrendaen
local.contributor.firstnameCatherine Men
local.contributor.firstnameLarsen
local.contributor.firstnameNatkunamen
local.contributor.firstnameAndreasen
local.relation.isfundedbyNHMRCen
local.relation.isfundedbyNHMRCen
local.relation.isfundedbyNHMRCen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailnkethees@une.edu.auen
local.output.categoryC1en
local.grant.numberAPP1052764en
local.grant.numberAPP1140709en
local.grant.numberAPP1120808en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited States of Americaen
local.identifier.runningnumbere01422-20en
local.format.startpage1en
local.format.endpage5en
local.identifier.scopusid85098662299en
local.peerreviewedYesen
local.identifier.volume65en
local.identifier.issue1en
local.access.fulltextYesen
local.contributor.lastnameSathkumaraen
local.contributor.lastnameHansenen
local.contributor.lastnameMiranda-Hernandezen
local.contributor.lastnameGovanen
local.contributor.lastnameRushen
local.contributor.lastnameHenningen
local.contributor.lastnameKetheesanen
local.contributor.lastnameKupzen
dc.identifier.staffune-id:nketheesen
local.profile.orcid0000-0002-4870-706Xen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/46928en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleDisparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Miceen
local.relation.fundingsourcenoteAustralian Institute of Tropical Health, Medicine (AITHM) Capacity Building Grant (15031), an AITHM scholarshipen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.relation.grantdescriptionNHMRC/APP1052764en
local.relation.grantdescriptionNHMRC/APP1140709en
local.relation.grantdescriptionNHMRC/APP1120808en
local.search.authorSathkumara, Harindra Den
local.search.authorHansen, Karynaen
local.search.authorMiranda-Hernandez, Socorroen
local.search.authorGovan, Brendaen
local.search.authorRush, Catherine Men
local.search.authorHenning, Larsen
local.search.authorKetheesan, Natkunamen
local.search.authorKupz, Andreasen
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.identifier.wosid000600658500036en
local.year.published2020en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/7e975f12-cd5f-4196-aed0-30e3e08df82een
local.subject.for2020320211 Infectious diseasesen
local.subject.for2020320701 Medical bacteriologyen
local.subject.seo2020200104 Prevention of human diseases and conditionsen
local.subject.seo2020240801 Human biological preventativesen
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School of Science and Technology
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