Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/46895
Title: Exploiting the Versatility of Polydopamine-Coated Nanoparticles to Deliver Nitric Oxide and Combat Bacterial Biofilm
Contributor(s): Adnan, Nik Nik M (author); Sadrearhami, Zahra (author); Bagheri, Ali  (author)orcid ; Nguyen, Thuy-Khanh (author); Wong, Edgar H H (author); Ho, Kitty K K (author); Lim, May (author); Kumar, Naresh (author); Boyer, Cyrille (author)
Publication Date: 2018-07
Early Online Version: 2018-05-28
DOI: 10.1002/marc.201800159
Handle Link: https://hdl.handle.net/1959.11/46895
Abstract: In this study, an antimicrobial platform in the form of nitric oxide (NO) gasreleasing polydopamine (PDA)-coated iron oxide nanoparticles (IONPs) is developed for combating bacterial biofilms. NO is bound to the PDA-coated IONPs via the reaction between NO and the secondary amine moieties on PDA to form N-diazeniumdiolate (NONOate) functionality. To impart colloidal stability to the nanoparticles in aqueous solutions (e.g., phosphate buffered saline (PBS) and bacteria cell culture media M9), a polymer bearing hydrophilic and amine pendant groups, P(OEGMA)-b-P(ABA), is synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization and is subsequently grafted onto the PDA-coated IONPs by employing the Schiff base/Michael addition reaction between o-quinone and a primary amine. These nanoparticles are able to effectively disperse Pseudomonas aeruginosa biofilms (up to 79% dispersal) at submicromolar NO concentrations. In addition, the nanoparticles demonstrate excellent bactericidal activity toward P. aeruginosa planktonic and biofilm cells (up to 5-log10 reduction).
Publication Type: Journal Article
Grant Details: ARC/FT12010096
Source of Publication: Macromolecular Rapid Communications, 39(13), p. 1-8
Publisher: Wiley-VCH Verlag GmbH & Co KGaA
Place of Publication: Germany
ISSN: 1521-3927
1022-1336
Fields of Research (FoR) 2020: 340302 Macromolecular materials
Socio-Economic Objective (SEO) 2020: 120304 Polymeric materials and paints
280105 Expanding knowledge in the chemical sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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