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https://hdl.handle.net/1959.11/46895
Title: | Exploiting the Versatility of Polydopamine-Coated Nanoparticles to Deliver Nitric Oxide and Combat Bacterial Biofilm | Contributor(s): | Adnan, Nik Nik M (author); Sadrearhami, Zahra (author); Bagheri, Ali (author) ; Nguyen, Thuy-Khanh (author); Wong, Edgar H H (author); Ho, Kitty K K (author); Lim, May (author); Kumar, Naresh (author); Boyer, Cyrille (author) | Publication Date: | 2018-07 | Early Online Version: | 2018-05-28 | DOI: | 10.1002/marc.201800159 | Handle Link: | https://hdl.handle.net/1959.11/46895 | Abstract: | In this study, an antimicrobial platform in the form of nitric oxide (NO) gasreleasing polydopamine (PDA)-coated iron oxide nanoparticles (IONPs) is developed for combating bacterial biofilms. NO is bound to the PDA-coated IONPs via the reaction between NO and the secondary amine moieties on PDA to form N-diazeniumdiolate (NONOate) functionality. To impart colloidal stability to the nanoparticles in aqueous solutions (e.g., phosphate buffered saline (PBS) and bacteria cell culture media M9), a polymer bearing hydrophilic and amine pendant groups, P(OEGMA)-b-P(ABA), is synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization and is subsequently grafted onto the PDA-coated IONPs by employing the Schiff base/Michael addition reaction between o-quinone and a primary amine. These nanoparticles are able to effectively disperse Pseudomonas aeruginosa biofilms (up to 79% dispersal) at submicromolar NO concentrations. In addition, the nanoparticles demonstrate excellent bactericidal activity toward P. aeruginosa planktonic and biofilm cells (up to 5-log10 reduction). | Publication Type: | Journal Article | Grant Details: | ARC/FT12010096 | Source of Publication: | Macromolecular Rapid Communications, 39(13), p. 1-8 | Publisher: | Wiley-VCH Verlag GmbH & Co KGaA | Place of Publication: | Germany | ISSN: | 1521-3927 1022-1336 |
Fields of Research (FoR) 2020: | 340302 Macromolecular materials | Socio-Economic Objective (SEO) 2020: | 120304 Polymeric materials and paints 280105 Expanding knowledge in the chemical sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Science and Technology |
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