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https://hdl.handle.net/1959.11/3987
Title: | Psychological impact of genetic testing for hereditary non-polyposis colorectal cancer | Contributor(s): | Meiser, B (author); Collins, V (author); Warren, R (author); Gaff, C (author); James, D (author); St John, B (author); Young, M (author); Harrop, K (author); Brown, Judith Elizabeth (author) | Publication Date: | 2004 | DOI: | 10.1111/j.1399-0004.2004.00339.x | Handle Link: | https://hdl.handle.net/1959.11/3987 | Abstract: | The psychological impact of predictive genetic testing for hereditary non-polyposis colorectal cancer was assessed in 114 individuals (32 carriers and 82 non-carriers) attending familial cancer clinics, using mailed self-administered questionnaires prior to, 2 weeks, 4 months and 12 months after carrier status disclosure. Compared to baseline, carriers showed a significant increase in mean scores for intrusive and avoidant thoughts about colorectal cancer 2 weeks (t=2.49; p=0.014) and a significant decrease in mean depression scores 2 weeks post-notification of result (t=-3.98; p<9.001) and 4 months post-notification of result (t=-3.22; p=0.002). For non-carriers, significant decreases in mean scores for intrusive and avoidant thoughts about colorectal cancer were observed at all follow-up assessment time points relative to baseline. Non-carriers also showed significant decreases from baseline in mean depression scores 2 weeks, 4 months and 12 months post-notification. Significant decreases from baseline for mean state anxiety scores were also observed for non-carriers 2 weeks post-notification (t=-3.99; p>0.001). These data indicate that predictive genetic testing for HNPCC leads to psychological benefits against non-carriers, and no adverse psychological outcomes were observed amongst carriers. | Publication Type: | Journal Article | Source of Publication: | Clinical Genetics, 66(6), p. 502-511 | Publisher: | Blackwell Publishing Ltd | Place of Publication: | Denmark | ISSN: | 0009-9163 | Fields of Research (FoR) 2008: | 160899 Sociology not elsewhere classified | Socio-Economic Objective (SEO) 2008: | 970116 Expanding Knowledge through Studies of Human Society | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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