Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/28198
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dc.contributor.authorTurner, J Ven
dc.contributor.authorAgatonovic-Kustrn, Sen
dc.contributor.authorWard, H R Gen
dc.date.accessioned2020-03-13T05:41:59Z-
dc.date.available2020-03-13T05:41:59Z-
dc.date.issued2015-12-28-
dc.identifier.citationFacts, Views & Vision in ObGyn, 7(4), p. 261-264en
dc.identifier.issn2684-4230en
dc.identifier.issn2032-0418en
dc.identifier.urihttps://hdl.handle.net/1959.11/28198-
dc.description.abstractClinical use of drugs is approved for specified clinical indication, route of administration, dose and population group. Off-label prescribing of a registered medicine occurs outside of these parameters and may be justified by pharmacology and physiology, as well as sufficient evidence from published clinical trials and reviews. Misoprostol and mifepristone in combination have recently been registered in Australia for medical termination of pregnancy in women of child-bearing age. There is good clinical evidence for efficacy and safety of misoprostol in uterine evacuation in both miscarriage and termination of pregnancy. The pharmacological effects of misoprostol on the uterus and clinical outcomes in both early miscarriage and abortion are comparable. Medical management of miscarriage with misoprostol in Australia is performed off-label. A woman presenting with first trimester miscarriage must be clearly informed that use of misoprostol in her case is for a non-approved indication. This raises the issue of inequity in her management compared with that of first trimester medical abortion, including being treated off-label and the potential cost of non-subsidised medication. The clinician must also be careful to use an evidence-based protocol that would withstand medicolegal challenge in the case of an adverse outcome.en
dc.languageenen
dc.publisherUniversa Pressen
dc.relation.ispartofFacts, Views & Vision in ObGynen
dc.rightsAttribution 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0*
dc.titleOff-label use of misoprostol in gynaecologyen
dc.typeJournal Articleen
dc.identifier.pmid27729972en
dcterms.accessRightsUNE Greenen
local.contributor.firstnameJ Ven
local.contributor.firstnameSen
local.contributor.firstnameH R Gen
local.subject.for2008110399 Clinical Sciences not elsewhere classifieden
local.subject.for2008111502 Clinical Pharmacology and Therapeuticsen
local.subject.seo2008920114 Reproductive System and Disordersen
local.subject.seo2008920206 Health Inequalitiesen
local.profile.schoolSchool of Rural Medicineen
local.profile.emailJoseph.Turner@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeBelgiumen
local.format.startpage261en
local.format.endpage264en
local.url.openhttps://www.fvvo.be/archive/volume-7/number-4/en
local.peerreviewedYesen
local.identifier.volume7en
local.identifier.issue4en
local.access.fulltextYesen
local.contributor.lastnameTurneren
local.contributor.lastnameAgatonovic-Kustrnen
local.contributor.lastnameWarden
dc.identifier.staffune-id:jturne59en
local.profile.orcid0000-0002-0023-4275en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/28198en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleOff-label use of misoprostol in gynaecologyen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorTurner, J Ven
local.search.authorAgatonovic-Kustrn, Sen
local.search.authorWard, H R Gen
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/cc399f1f-bc3b-4d6d-951e-62131615f005en
local.istranslatedNoen
local.uneassociationNoen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.identifier.wosid000377853700009en
local.year.published2015en
local.fileurl.openhttps://rune.une.edu.au/web/retrieve/cc399f1f-bc3b-4d6d-951e-62131615f005en
local.fileurl.openpublishedhttps://rune.une.edu.au/web/retrieve/cc399f1f-bc3b-4d6d-951e-62131615f005en
local.subject.for2020320299 Clinical sciences not elsewhere classifieden
local.subject.for2020321402 Clinical pharmacology and therapeuticsen
local.subject.seo2020200204 Health inequalitiesen
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School of Rural Medicine
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