Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/27931
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dc.contributor.authorBaran, Patrycjaen
dc.contributor.authorMayo, Sheridanen
dc.contributor.authorMcCormack, Mikkaelaen
dc.contributor.authorPacile, Serenaen
dc.contributor.authorTromba, Giulianaen
dc.contributor.authorDullin, Christianen
dc.contributor.authorZanconati, Fabrizioen
dc.contributor.authorArfelli, Fulviaen
dc.contributor.authorDreossi, Diegoen
dc.contributor.authorFox, Janeen
dc.contributor.authorProdanovic, Zdenkaen
dc.contributor.authorCholewa, Marianen
dc.contributor.authorQuiney, Harryen
dc.contributor.authorDimmock, Matthewen
dc.contributor.authorNesterets, Yakoven
dc.contributor.authorThompson, Darrenen
dc.contributor.authorBrennan, Patricken
dc.contributor.authorGureyev, Timuren
dc.date.accessioned2020-01-13T01:40:03Z-
dc.date.available2020-01-13T01:40:03Z-
dc.date.issued2018-12-
dc.identifier.citationIEEE Transactions on Medical Imaging, 37(12), p. 2642-2650en
dc.identifier.issn1558-254Xen
dc.identifier.issn0278-0062en
dc.identifier.urihttps://hdl.handle.net/1959.11/27931-
dc.description.abstractHistopathological analysis is the current gold standard in breast cancer diagnosis and management, however, as imaging technology improves, the amount of potential diagnostic information that may be demonstrable radiologically should also increase. We aimed to evaluate the potential clinical usefulness of 3-D phase-contrast micro-computed tomography (micro-CT) imaging at high spatial resolutions as an adjunct to conventional histological microscopy. Ten breast tissue specimens, 2 mm in diameter, were scanned at the SYRMEP beamline of the Elettra Synchrotron using the propagation-based phase-contrast micro-tomography method. We obtained 1.2 μm pixel size images, which were analyzed and compared with corresponding histological sections examined under light microscopy. To evaluate the effect of spatial resolution on breast cancer diagnosis, scans with four different pixel sizes were also performed. Our comparative analysis revealed that high-resolution images can enable, at a near-histological level, detailed architectural assessment of tissue that may permit increased breast cancer diagnostic sensitivity and specificity when compared with current imaging practices. The potential clinical applications of this method are also discussed.en
dc.languageenen
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.relation.ispartofIEEE Transactions on Medical Imagingen
dc.titleHigh-Resolution X-Ray Phase-Contrast 3-D Imaging of Breast Tissue Specimens as a Possible Adjunct to Histopathologyen
dc.typeJournal Articleen
dc.identifier.doi10.1109/TMI.2018.2845905en
local.contributor.firstnamePatrycjaen
local.contributor.firstnameSheridanen
local.contributor.firstnameMikkaelaen
local.contributor.firstnameSerenaen
local.contributor.firstnameGiulianaen
local.contributor.firstnameChristianen
local.contributor.firstnameFabrizioen
local.contributor.firstnameFulviaen
local.contributor.firstnameDiegoen
local.contributor.firstnameJaneen
local.contributor.firstnameZdenkaen
local.contributor.firstnameMarianen
local.contributor.firstnameHarryen
local.contributor.firstnameMatthewen
local.contributor.firstnameYakoven
local.contributor.firstnameDarrenen
local.contributor.firstnamePatricken
local.contributor.firstnameTimuren
local.subject.for2008111202 Cancer Diagnosisen
local.subject.seo2008970111 Expanding Knowledge in the Medical and Health Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailynestere@une.edu.auen
local.profile.emailtgureyev@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited States of Americaen
local.format.startpage2642en
local.format.endpage2650en
local.identifier.scopusid85048511541en
local.peerreviewedYesen
local.identifier.volume37en
local.identifier.issue12en
local.contributor.lastnameBaranen
local.contributor.lastnameMayoen
local.contributor.lastnameMcCormacken
local.contributor.lastnamePacileen
local.contributor.lastnameTrombaen
local.contributor.lastnameDullinen
local.contributor.lastnameZanconatien
local.contributor.lastnameArfellien
local.contributor.lastnameDreossien
local.contributor.lastnameFoxen
local.contributor.lastnameProdanovicen
local.contributor.lastnameCholewaen
local.contributor.lastnameQuineyen
local.contributor.lastnameDimmocken
local.contributor.lastnameNesteretsen
local.contributor.lastnameThompsonen
local.contributor.lastnameBrennanen
local.contributor.lastnameGureyeven
dc.identifier.staffune-id:ynestereen
dc.identifier.staffune-id:tgureyeven
local.profile.orcid0000-0002-1103-0649en
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local.identifier.unepublicationidune:1959.11/27931en
local.date.onlineversion2018-06-11-
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
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dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
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local.title.maintitleHigh-Resolution X-Ray Phase-Contrast 3-D Imaging of Breast Tissue Specimens as a Possible Adjunct to Histopathologyen
local.relation.fundingsourcenoteNational Breast Cancer Foundation (Australia)en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorBaran, Patrycjaen
local.search.authorMayo, Sheridanen
local.search.authorMcCormack, Mikkaelaen
local.search.authorPacile, Serenaen
local.search.authorTromba, Giulianaen
local.search.authorDullin, Christianen
local.search.authorZanconati, Fabrizioen
local.search.authorArfelli, Fulviaen
local.search.authorDreossi, Diegoen
local.search.authorFox, Janeen
local.search.authorProdanovic, Zdenkaen
local.search.authorCholewa, Marianen
local.search.authorQuiney, Harryen
local.search.authorDimmock, Matthewen
local.search.authorNesterets, Yakoven
local.search.authorThompson, Darrenen
local.search.authorBrennan, Patricken
local.search.authorGureyev, Timuren
local.istranslatedNoen
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.year.available2018en
local.year.published2018en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/eefce02f-1c1f-42bf-bacc-2f0259c84d0den
local.subject.for2020321102 Cancer diagnosisen
local.subject.seo2020280103 Expanding knowledge in the biomedical and clinical scienceen
local.subject.seo2020280114 Expanding knowledge in Indigenous studiesen
local.subject.seo2020280112 Expanding knowledge in the health sciencesen
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School of Science and Technology
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