Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/27743
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dc.contributor.authorGharib-Naseri, Ken
dc.contributor.authorKheravii, S Ken
dc.contributor.authorKeerqin, Cen
dc.contributor.authorMorgan, Nen
dc.contributor.authorSwick, R Aen
dc.contributor.authorChoct, Men
dc.contributor.authorWu, S-Ben
dc.date.accessioned2019-11-08T05:07:10Z-
dc.date.available2019-11-08T05:07:10Z-
dc.identifier.citationPoultry Science, p. 1-11en
dc.identifier.issn0032-5791en
dc.identifier.issn1525-3171en
dc.identifier.urihttps://hdl.handle.net/1959.11/27743-
dc.description.abstractSubclinical necrotic enteritis (NE) is primarily caused by the gram-positive bacterium, Clostridium perfringens (Cp). The trend towards removal of in-feed antimicrobials and subsequent increased emergence of infection in poultry has resulted in a wide interest in better understanding of the mechanism behind this disease. The virulence of NE, to a large extent, depends on the virulence of Cp strains. Thus, this study was to assess how 2 different strains of Cp affect performance and gut characteristics of broiler chickens. Ross 308 male broilers (n = 468) were assigned to a 2 × 3 factorial arrangement of treatments with antibiotics (Salinomycin at 72 ppm and zinc bacitracin at 50 ppm −, or +) and challenge (non-challenge, Cp EHE-NE18, or Cp WER-NE36). Oral administration of Eimeria oocysts (day 9) followed by inoculation with 1 mL 108 CFU Cp strains (day 14 and 15) were used to induce NE. Broiler performance was analyzed at day 10, 24, and 35. On day 16, intestinal lesion score and intestinal pH were evaluated and samples of cecal content were analyzed for bacterial counts and short-chain fatty acid concentrations (SCFA). Birds in both challenged groups showed higher feed conversion ratio (FCR), lower weight gain (P < 0.001), increased lesion scores in the jejunum (P < 0.01), and reduced pH in the ileum and cecum (P < 0.01), compared to the non-challenged birds. They also showed decreased numbers of Bacillus spp. (P < 0.001), and Ruminococcus spp. (P < 0.01) in the cecal content. On day 35, the NE36 challenged birds had a lower weight gain (P < 0.001) and higher FCR (P < 0.001) compared to the NE18 challenged birds. Interestingly, cecal Lactobacillus and lactate were increased by the NE challenge (P < 0.001), and to a greater extent in birds challenged with NE36 compared to the NE18 strain (P < 0.001). This study suggests that Cp strains varying in virulence produce different levels of disease in broiler chickens through modulating the gut environment, intestinal microbiota, and SCFA profile to different extents.en
dc.languageenen
dc.publisherOxford University Pressen
dc.relation.ispartofPoultry Scienceen
dc.titleTwo different Clostridium perfringens strains produce different levels of necrotic enteritis in broiler chickensen
dc.typeJournal Articleen
dc.identifier.doi10.3382/ps/pez480en
dc.identifier.pmid31424518en
local.subject.for2008070204 Animal Nutritionen
local.subject.for2008070203 Animal Managementen
local.subject.seo2008839901 Animal Welfareen
local.subject.seo2008920109 Infectious Diseasesen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolAdministrationen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailkgharib2@une.edu.auen
local.profile.emailsqassim2@une.edu.auen
local.profile.emailckeerqi2@une.edu.auen
local.profile.emailnmorga20@une.edu.auen
local.profile.emailrswick@une.edu.auen
local.profile.emailmchoct@une.edu.auen
local.profile.emailswu3@une.edu.auen
local.output.categoryC1en
local.publisher.placeUnited States of Americaen
local.format.startpage1en
local.format.endpage11en
local.peerreviewedYesen
dc.identifier.staffune-id:kgharib2en
dc.identifier.staffune-id:sqassim2en
dc.identifier.staffune-id:ckeerqi2en
dc.identifier.staffune-id:nmorga20en
dc.identifier.staffune-id:rswicken
dc.identifier.staffune-id:mchocten
dc.identifier.staffune-id:swu3en
local.profile.orcid0000-0002-4157-1489en
local.profile.orcid0000-0002-9663-2365en
local.profile.orcid0000-0003-3376-1677en
local.profile.orcid0000-0002-1790-6015en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/27743en
local.date.onlineversion2019-08-19-
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.istranslatedNoen
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
Appears in Collections:Journal Article
School of Environmental and Rural Science
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