Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/27627
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dc.contributor.authorAliloo, Hen
dc.contributor.authorPryce, J Een
dc.contributor.authorGozalez-Recio, Oen
dc.contributor.authorCocks, B Gen
dc.contributor.authorHayes, B Jen
dc.date.accessioned2019-10-13T22:06:43Z-
dc.date.available2019-10-13T22:06:43Z-
dc.date.issued2015-
dc.identifier.citationProceedings of the Association for the Advancement of Animal Breeding and Genetics, v.21, p. 358-361en
dc.identifier.isbn9780646945545en
dc.identifier.issn1328-3227en
dc.identifier.urihttps://hdl.handle.net/1959.11/27627-
dc.description.abstractIt has been suggested that traits associated with fitness, such as fertility, may have proportionately more genetic variation arising from non-additive effects than traits with higher heritability, such as milk yield. Here, we performed a large genome scan with 408,255 single nucleotide polymorphism (SNP) markers to identify chromosomal regions associated with dominance and epistatic (pairwise additive × additive) variability in milk yield and fertility (measured by calving interval), using 7,055 genotyped and phenotyped Holstein cows. The results were subsequently replicated in an independent set of 3,795 Jersey cows. We identified genome regions with replicated dominance effects for milk yield on Bos taurus autosomes (BTA) 2, 3, 5, 26 and 27 whereas SNPs with replicated dominance effects for fertility were found on BTA 1, 2, 3, 7, 23, 25 and 28. A number of significant epistatic effects for milk yield on BTA 14 were found across breeds. However, these were likely to be associated with the mutation in the diacylglycerol O-acyltransferase 1 (DGAT1) gene, given that the associations were no longer significant when the full additive effect of the DGAT1 mutation was included in the epistatic model. The results of our study suggest that individual non-additive effects make a small contribution to the genetic variation of milk yield and fertility.en
dc.languageenen
dc.publisherAssociation for the Advancement of Animal Breeding and Genetics (AAABG)en
dc.relation.ispartofProceedings of the Association for the Advancement of Animal Breeding and Geneticsen
dc.titleA Genome-Wide Association Study of Non-Additive Effects for Milk Yield and Fertility in Holstein and Jersey Dairy Cattleen
dc.typeConference Publicationen
dc.relation.conferenceAAABG 2015: 21st Conference of the Association for the Advancement of Animal Breeding and Geneticsen
dcterms.accessRightsBronzeen
local.contributor.firstnameHen
local.contributor.firstnameJ Een
local.contributor.firstnameOen
local.contributor.firstnameB Gen
local.contributor.firstnameB Jen
local.subject.for2008060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)en
local.subject.for2008070201 Animal Breedingen
local.subject.for2008060408 Genomicsen
local.subject.seo2008839999 Animal Production and Animal Primary Products not elsewhere classifieden
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailhaliloo@une.edu.auen
local.output.categoryE1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.date.conference28th - 30th September, 2015en
local.conference.placeLorne, Australiaen
local.publisher.placeArmidale, Australiaen
local.format.startpage358en
local.format.endpage361en
local.url.openhttp://www.aaabg.org/proceedings/2015/Aliloo21358.pdfen
local.peerreviewedYesen
local.identifier.volume21en
local.access.fulltextYesen
local.contributor.lastnameAlilooen
local.contributor.lastnamePryceen
local.contributor.lastnameGozalez-Recioen
local.contributor.lastnameCocksen
local.contributor.lastnameHayesen
dc.identifier.staffune-id:halilooen
local.profile.orcid0000-0002-5587-6929en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/27627en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleA Genome-Wide Association Study of Non-Additive Effects for Milk Yield and Fertility in Holstein and Jersey Dairy Cattleen
local.output.categorydescriptionE1 Refereed Scholarly Conference Publicationen
local.relation.urlhttp://www.aaabg.org/aaabghome/proceedings21.phpen
local.conference.detailsAAABG 2015: 21st Conference of the Association for the Advancement of Animal Breeding and Genetics, Lorne, Australia, 28th - 30th September, 2015en
local.search.authorAliloo, Hen
local.search.authorPryce, J Een
local.search.authorGozalez-Recio, Oen
local.search.authorCocks, B Gen
local.search.authorHayes, B Jen
local.uneassociationUnknownen
local.year.published2015-
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/2b9e38a2-0094-442d-9fa9-4147bac7e51ben
local.subject.for2020310506 Gene mappingen
local.subject.for2020300305 Animal reproduction and breedingen
local.subject.for2020310509 Genomicsen
local.subject.seo2020109999 Other animal production and animal primary products not elsewhere classifieden
local.date.start2015-09-28-
local.date.end2015-09-30-
local.profile.affiliationtypeUnknownen
local.profile.affiliationtypeUnknownen
local.profile.affiliationtypeUnknownen
local.profile.affiliationtypeUnknownen
local.profile.affiliationtypeUnknownen
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School of Environmental and Rural Science
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