Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/26965
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tully, Phillip J | en |
dc.contributor.author | Hanon, Olivier | en |
dc.contributor.author | Cosh, Suzanne | en |
dc.contributor.author | Tzourio, Christophe | en |
dc.date.accessioned | 2019-05-28T00:25:34Z | - |
dc.date.available | 2019-05-28T00:25:34Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.citation | Journal of Hypertension, 34(6), p. 1027-1035 | en |
dc.identifier.issn | 0263-6352 | en |
dc.identifier.issn | 1473-5598 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/26965 | - |
dc.description.abstract | <p><b>Objective:</b> Diuretic drugs have been a mainstay of hypertension treatment in the elderly however their dementia sparing effects are under-reported. The objective was to quantify dementia risk in relation to diuretic antihypertensive drugs.</p> <p><b>Methods:</b> Electronic databases were searched until June 2015. Eligibility criteria: population, adults without dementia from primary care, community cohort, residential/institutionalized, or randomized controlled trial; exposure, diuretic antihypertensive drug; comparison, no diuretic drug, other or no antihypertensive drug, placebo-control; outcome, incident dementia diagnosed by standardized criteria. Adjusted hazard ratios (HR) with 95% confidence intervals (CI) were pooled in fixed-effects models with RevMan 5.3 (The Nordic Cochrane Centre, Copenhagen, Denmark) and the findings rated according to The Grading of Recommendations Assessment, Development and Evaluation criteria.</p> <p><b>Results:</b> A total of 15 articles were included (52 599 persons, 3444 dementia cases, median age 76.1 years) and median follow-up was 6.1 years. Diuretics were associated with reduced dementia risk (HR 0.83; 95% CI 0.76-0.91, <i>P</i> < 0.0001, I<sup>2</sup> = 0) and Alzheimer's disease risk (HR 0.82; 95% CI 0.71-0.94, <i>P</i> = 0.004, I<sup>2</sup> = 0). Stratified analysis indicated a difference between potassium sparing, thiazide and loop diuretics (<i>P</i> = 0.01). Risk estimates were generally consistent comparing monotherapy vs. combination therapy, study design and follow-up. Meta-regression showed that demographics, stroke, heart failure, diabetes, liver disease, attrition, mortality rate, cognitive function, and apolipoprotein E allele did not moderate the results.</p> <p><b>Conclusion:</b> Diuretic antihypertensive drugs were associated with a consistent reduction in dementia risk without heterogeneity, pointing to generalizability of these findings.</p> | en |
dc.language | en | en |
dc.publisher | Lippincott Williams & Wilkins | en |
dc.relation.ispartof | Journal of Hypertension | en |
dc.title | Diuretic antihypertensive drugs and incident dementia risk: a systematic review, meta-analysis and meta-regression of prospective studies | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1097/HJH.0000000000000868 | en |
dc.identifier.pmid | 26886565 | en |
local.contributor.firstname | Phillip J | - |
local.contributor.firstname | Olivier | - |
local.contributor.firstname | Suzanne | - |
local.contributor.firstname | Christophe | - |
local.subject.for2008 | 170102 Developmental Psychology and Ageing | en |
local.subject.for2008 | 110201 Cardiology (incl. Cardiovascular Diseases) | en |
local.subject.for2008 | 110319 Psychiatry (incl. Psychotherapy) | en |
local.subject.seo2008 | 920103 Cardiovascular System and Diseases | en |
local.subject.seo2008 | 970117 Expanding Knowledge in Psychology and Cognitive Sciences | en |
local.subject.seo2008 | 970111 Expanding Knowledge in the Medical and Health Sciences | en |
local.profile.school | School of Psychology | en |
local.profile.school | School of Psychology | en |
local.profile.email | ptully2@une.edu.au | en |
local.profile.email | scosh@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | - |
local.record.institution | University of New England | - |
local.publisher.place | United States of America | en |
local.format.startpage | 1027 | en |
local.format.endpage | 1035 | en |
local.identifier.scopusid | 84958793938 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 34 | en |
local.identifier.issue | 6 | en |
local.title.subtitle | a systematic review, meta-analysis and meta-regression of prospective studies | - |
local.contributor.lastname | Tully | - |
local.contributor.lastname | Hanon | - |
local.contributor.lastname | Cosh | - |
local.contributor.lastname | Tzourio | - |
dc.identifier.staff | une-id:ptully2 | en |
dc.identifier.staff | une-id:scosh | en |
local.profile.orcid | 0000-0003-2807-1313 | en |
local.profile.orcid | 0000-0002-8003-3704 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/26965 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Diuretic antihypertensive drugs and incident dementia risk | - |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | - |
local.search.author | Tully, Phillip J | - |
local.search.author | Hanon, Olivier | - |
local.search.author | Cosh, Suzanne | - |
local.search.author | Tzourio, Christophe | - |
local.uneassociation | Unknown | en |
local.atsiresearch | No | - |
local.sensitive.cultural | No | - |
local.identifier.wosid | 000375146000002 | en |
local.year.published | 2016 | - |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/797b0e07-7b43-4ebb-b614-b35b5f7854dd | - |
local.subject.for2020 | 320221 Psychiatry (incl. psychotherapy) | en |
local.subject.for2020 | 320101 Cardiology (incl. cardiovascular diseases) | en |
local.subject.for2020 | 520106 Psychology of ageing | en |
local.subject.seo2020 | 280103 Expanding knowledge in the biomedical and clinical science | en |
local.subject.seo2020 | 280112 Expanding knowledge in the health sciences | en |
local.subject.seo2020 | 280121 Expanding knowledge in psychology | en |
dc.notification.token | d367187c-3b98-4275-99b8-a117644ec899 | - |
local.codeupdate.date | 2022-03-25T11:14:07.983 | - |
local.codeupdate.eperson | ghart4@une.edu.au | - |
local.codeupdate.finalised | true | - |
local.original.for2020 | 320101 Cardiology (incl. cardiovascular diseases) | - |
local.original.for2020 | 320221 Psychiatry (incl. psychotherapy) | - |
local.original.for2020 | 520101 Child and adolescent development | - |
local.original.for2020 | 520106 Psychology of ageing | - |
local.original.seo2020 | undefined | - |
local.original.seo2020 | 280103 Expanding knowledge in the biomedical and clinical science | - |
local.original.seo2020 | 280121 Expanding knowledge in psychology | - |
local.original.seo2020 | 280112 Expanding knowledge in the health sciences | - |
local.original.seo2020 | 280114 Expanding knowledge in Indigenous studies | - |
Appears in Collections: | Journal Article School of Psychology |
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