Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/26655
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dc.contributor.authorSharpley, Christopher Fen
dc.contributor.authorBitsika, Vickien
dc.contributor.authorMcMillan, Mary Een
dc.contributor.authorJesulola, Emmanuelen
dc.contributor.authorAgnew, Linda Len
dc.date.accessioned2019-04-08T00:42:33Z-
dc.date.available2019-04-08T00:42:33Z-
dc.date.issued2018-08-10-
dc.identifier.citationNeuropsychiatric Disease and Treatment, v.14, p. 2007-2016en
dc.identifier.issn1178-2021en
dc.identifier.urihttps://hdl.handle.net/1959.11/26655-
dc.description.abstractPurpose: Depression remains difficult to treat in all cases, and further investigation of the role of genetic and environmental factors may be valuable. This study was designed to investigate the association between the short (s) versus non-short (non-s) 5HTTLPR variants, presence of childhood stressors and recent life stressors, and depression, and to do so at two levels that would expose the associations between total depression scores and also individual depression items. Materials and methods: Two hundred and forty-nine volunteers from one of the Australian Electoral Office electorates covering a large rural land area completed a series of questionnaires about childhood and recent life stress and depression, and provided a buccal cell sample for genotyping the 5-HTTLPR polymorphism into s versus non-s carriers. Results: Although there were no significant differences in the depression scores of the s-carriers versus the non-s carriers, each subtype of the 5-HTTLPR polymorphism showed different patterns of association between childhood stress and depression symptoms, and between recent life stress and depression symptoms. Conclusion: Individualization of therapy for depression may be achieved through consideration of the specific associations that patients exhibit between life stress, 5-HTTLPR polymorphism, and depression symptomatology.en
dc.languageenen
dc.publisherDove Medical Press Ltden
dc.relation.ispartofNeuropsychiatric Disease and Treatmenten
dc.titleAssociations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australiansen
dc.typeJournal Articleen
dc.identifier.doi10.2147/NDT.S168291en
dc.identifier.pmid30127611en
dcterms.accessRightsGolden
local.contributor.firstnameChristopher Fen
local.contributor.firstnameVickien
local.contributor.firstnameMary Een
local.contributor.firstnameEmmanuelen
local.contributor.firstnameLinda Len
local.subject.for2008110999 Neurosciences not elsewhere classifieden
local.subject.seo2008920111 Nervous System and Disordersen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailcsharpl3@une.edu.auen
local.profile.emailvbitsik2@une.edu.auen
local.profile.emailmrookle2@une.edu.auen
local.profile.emaillagnew2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited Kingdomen
local.format.startpage2007en
local.format.endpage2016en
local.peerreviewedYesen
local.identifier.volume14en
local.access.fulltextYesen
local.contributor.lastnameSharpleyen
local.contributor.lastnameBitsikaen
local.contributor.lastnameMcMillanen
local.contributor.lastnameJesulolaen
local.contributor.lastnameAgnewen
dc.identifier.staffune-id:csharpl3en
dc.identifier.staffune-id:vbitsik2en
dc.identifier.staffune-id:mrookle2en
dc.identifier.staffune-id:lagnew2en
local.profile.orcid0000-0001-7922-4848en
local.profile.orcid0000-0003-2518-6684en
local.profile.orcid0000-0002-2336-3985en
local.profile.orcid0000-0002-2803-0995en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/26655en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleAssociations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australiansen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorSharpley, Christopher Fen
local.search.authorBitsika, Vickien
local.search.authorMcMillan, Mary Een
local.search.authorJesulola, Emmanuelen
local.search.authorAgnew, Linda Len
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School of Science and Technology
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