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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/26602
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dc.contributor.authorMurugananthan, Kalamathyen
dc.contributor.authorCoonghe, Pethirupillai A Den
dc.contributor.authorNoordeen, Faseehaen
dc.contributor.authorKetheesan, Natkunamen
dc.date.accessioned2019-04-03T01:44:39Z-
dc.date.available2019-04-03T01:44:39Z-
dc.date.issued2018-06-
dc.identifier.citationVirusDisease, 29(2), p. 199-202en
dc.identifier.issn2347-3517en
dc.identifier.issn2347-3584en
dc.identifier.urihttps://hdl.handle.net/1959.11/26602-
dc.description.abstractA total of 765 blood samples collected from dengue suspected patients admitted to a Teaching Hospital in Sri Lanka were used to compare a rapid ICT assay with a standard ELISA for the detection of anti-dengue virus (DENV) IgM and IgG. Detection accuracy indices including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Chi square and Cohen's kappa values were determined for the ICT assay using the ELISA as a comparator for the detection of anti-DENV IgM and IgG. The rapid ICT assay showed a sensitivity of 64%, specificity of 75%, NPV of 68% and PPV of 72% for anti-DENV IgM detection. However, all the accuracy indices were relatively higher for the anti-DENV IgG detection by the ICT assay than those for anti-DENV IgM detection. Despite the low sensitivity for anti-DENV IgM detection by the ICT assay, considering the limitations in using ELISAs in resource limited regions, rapid ICT assays would be useful for the detection of more recent DENV infections. As many patients present after fever days 5 in the study area, anti-DENV IgM/IgG would be the suitable marker to be detected by rapid ICT assays in such areas.en
dc.languageenen
dc.publisherSpringer (India) Private Ltden
dc.relation.ispartofVirusDiseaseen
dc.titleComparison of a rapid immuno-chromatography assay with a standard ELISA for the detection of IgM and IgG antibodies against dengue virusesen
dc.typeJournal Articleen
dc.identifier.doi10.1007/s13337-018-0440-xen
dc.identifier.pmid29911153en
local.contributor.firstnameKalamathyen
local.contributor.firstnamePethirupillai A Den
local.contributor.firstnameFaseehaen
local.contributor.firstnameNatkunamen
local.subject.for2008119999 Medical and Health Sciences not elsewhere classifieden
local.subject.seo2008920109 Infectious Diseasesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailnkethees@une.edu.auen
local.output.categoryC1en
local.grant.numberHETC JEN/O-MED/N7en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeIndiaen
local.format.startpage199en
local.format.endpage202en
local.identifier.scopusid85045473955en
local.peerreviewedYesen
local.identifier.volume29en
local.identifier.issue2en
local.contributor.lastnameMurugananthanen
local.contributor.lastnameCoongheen
local.contributor.lastnameNoordeenen
local.contributor.lastnameKetheesanen
dc.identifier.staffune-id:nketheesen
local.profile.orcid0000-0002-4870-706Xen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/26602en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleComparison of a rapid immuno-chromatography assay with a standard ELISA for the detection of IgM and IgG antibodies against dengue virusesen
local.relation.fundingsourcenoteHigher Education for the 21st Century (HETC) Granten
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorMurugananthan, Kalamathyen
local.search.authorCoonghe, Pethirupillai A Den
local.search.authorNoordeen, Faseehaen
local.search.authorKetheesan, Natkunamen
local.uneassociationUnknownen
local.year.published2018en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/694fd07d-a0ef-4ebb-8cfa-dd36c5281f08en
local.subject.for2020320211 Infectious diseasesen
local.subject.for2020320701 Medical bacteriologyen
local.subject.seo2020200104 Prevention of human diseases and conditionsen
dc.notification.tokeneea1ebc1-e85c-49fe-9da0-5553ab2dc6f4en
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