Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/23293
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dc.contributor.authorStrucken, Evaen
dc.contributor.authorBrockmann, Gudrunen
dc.date.accessioned2018-06-18T16:05:00Z-
dc.date.issued2012-
dc.identifier.citationSymposium "Milchrind" Programm, p. 5-5en
dc.identifier.urihttps://hdl.handle.net/1959.11/23293-
dc.languagedeen
dc.publisherHumboldt-Universitat zu Berlinen
dc.relation.ispartofSymposium "Milchrind" Programmen
dc.titleZeitabhängige genetische Effekte während der Laktation in Deutschen Holstein Rindernen
dc.typeConference Publicationen
dc.relation.conferenceSymposium "Milchrind"en
dc.subject.keywordsAnimal Breedingen
dc.subject.keywordsGenomicsen
local.contributor.firstnameEvaen
local.contributor.firstnameGudrunen
local.subject.for2008070201 Animal Breedingen
local.subject.for2008060408 Genomicsen
local.subject.seo2008830302 Dairy Cattleen
local.subject.seo2008970107 Expanding Knowledge in the Agricultural and Veterinary Sciencesen
local.subject.seo2008830507 Unprocessed or Minimally Processed Milken
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailestrucke@une.edu.auen
local.output.categoryE3en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20180511-165158en
local.date.conference29th November, 2012en
local.conference.placeBerlin, Germanyen
local.publisher.placeBerlin, Germanyen
local.format.startpage5en
local.format.endpage5en
local.contributor.lastnameStruckenen
local.contributor.lastnameBrockmannen
dc.title.translatedTime-dependent genetic effects during a lactation of German Holstein cowsen
dc.identifier.staffune-id:estruckeen
local.booktitle.translatedSymposium Dairy "Cow" Programmen
local.profile.orcid0000-0002-2715-0733en
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:23477en
dc.identifier.academiclevelAcademicen
local.abstract.englishThe variability of milk production during a lactation can be seen directly in the daily yields. However, because high producing dairy cows develop an energy deficit especially in early lactation, which can have far-reaching consequences, it is sensible to breed for a low production yield in the first lactation weeks. Simultaneously, a good persistency can improve the overall yield to satisfy the farmers' and consumers' demands. From mammogenesis to actual milk synthesis in the mammary glands, many time points and mechanisms take part in the physiological time-dependent expression of milk. The largest complexes involved in milk production cover hormone and growth factors, feed intake and digestion, cell activity, nutrient transportation and synthesis. Despite these various starting points that impact upon milk production, only few genes have been identified. This could be due to many association studies using averaged yields and therefore not being able to detect genes that are only relevant during a specific time-point. We developed an approach to carry out association studies in regards to specific lactation periods. These periods were defined as the yield increase before the maximum, the persistency, and the overall level of production. With this approach we were able to show that the DGAT1 gene expresses its known genotype effects only after lactation day 40, and that several groups of markers are significant for the three different production periods. Further, gene enrichment studies showed that genes with different functions were accumulated around significant markers. Such gene groups were involved in the regulation of cell growth, gene expression and transcript regulation, the energy supply of cells, fat and protein synthesis, and immune response, which were specific for individual periods. Time-dependent association studies can provide new insights into the regulation of milk production. We could asses the processes of milk production that will be altered when breeding for significant markers. Genomic selection could incorporate time-dependencies and thus selectively change the production curve to improve the overall yield as well as animal health and fertility.en
local.title.maintitleZeitabhängige genetische Effekte während der Laktation in Deutschen Holstein Rindernen
local.output.categorydescriptionE3 Extract of Scholarly Conference Publicationen
local.conference.detailsSymposium "Milchrind", Berlin, Germany, 29th November 2012en
local.search.authorStrucken, Evaen
local.search.authorBrockmann, Gudrunen
local.uneassociationUnknownen
local.year.published2012en
local.subject.for2020300305 Animal reproduction and breedingen
local.subject.for2020310509 Genomicsen
local.subject.seo2020100402 Dairy cattleen
local.subject.seo2020280101 Expanding knowledge in the agricultural, food and veterinary sciencesen
local.subject.seo2020100606 Unprocessed or minimally processed milken
local.date.start2012-11-29-
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School of Environmental and Rural Science
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