Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22956
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dc.contributor.authorStrucken, Evaen
dc.contributor.authorSchmitt, A Oen
dc.contributor.authorBergfeld, Uen
dc.contributor.authorJurke, Ien
dc.contributor.authorReissmann, Men
dc.contributor.authorBrockmann, G Aen
dc.date.accessioned2018-05-07T13:48:00Z-
dc.date.issued2014-
dc.identifier.citationJournal of Animal Science, 92(5), p. 1939-1944en
dc.identifier.issn1525-3163en
dc.identifier.issn0021-8812en
dc.identifier.urihttps://hdl.handle.net/1959.11/22956-
dc.description.abstractWe present results from a genomewide association study (GWAS) and a single-marker association study. The GWAS was performed with the Illumina PorcineSNP60 BeadChip from which 5 markers were selected for a validation analysis. Genetic effects were estimated for feed intake, weight gain, and traits of fat and muscle tissue in German Landrace boars kept on performance test stations. The GWAS was performed in a population of 288 boars and the validation study for another 432 boars. No statistically significant effect was found in the GWAS after adjusting for multiple testing. Effects of 2 markers, which were significant genomewide before correction for multiple testing (P < 0.00005), could be confirmed in the validation study. The major allele of marker ALGA0056781 on SSC1 was positively associated with both higher weight gain and fat deposition. The effect on live-weight gain was 2.25 g/d in the GWAS (P=0.0003) and 3.73 g/d in the validation study (P=0.01) and for back fat thickness was 0.15 mm in the GWAS (P < 0.0001) and 0.20 mm in the validation study (P=0.02). The marker had similar effects on test-day weight gain (GWAS: 3.85 g/d, P=0.001; validation study: 6.80 g/d, P=0.003) and back fat area (GWAS: 0.27 ㎠ , P < 0.0001; validation study: 0.35 ㎠ , P=0.03). Marker ASGA0056782 on SSC13 was associated with live-weight gain. The major allele had negative effects in both studies (GWAS: -4.88 g/d, P < 0.0001; validation study: -3.75 g/d, P=0.02). The effects of these 2 markers would have been excluded based on the GWAS alone but were shown to be significantly trait associated in the validation study indicating a false-negative result. The G protein-coupled receptor 126 (GPR126) gene approximately 200 kb downstream of marker ALGA0001781 was shown to be associated with human height and therefore might explain the association with weight gain in pigs. Several traits were affected in an economically desired direction by the minor allele of the markers, pointing to the possibility of improvement through further selection.en
dc.languageenen
dc.publisherOxford University Pressen
dc.relation.ispartofJournal of Animal Scienceen
dc.titleGenomewide study and validation of markers associated with production traits in German Landrace boars1en
dc.typeJournal Articleen
dc.identifier.doi10.2527/jas.2013-7247en
dc.subject.keywordsGenomicsen
dc.subject.keywordsAnimal Breedingen
local.contributor.firstnameEvaen
local.contributor.firstnameA Oen
local.contributor.firstnameUen
local.contributor.firstnameIen
local.contributor.firstnameMen
local.contributor.firstnameG Aen
local.subject.for2008060408 Genomicsen
local.subject.for2008070201 Animal Breedingen
local.subject.seo2008830599 Primary Animal Products not elsewhere classifieden
local.subject.seo2008970107 Expanding Knowledge in the Agricultural and Veterinary Sciencesen
local.subject.seo2008830308 Pigsen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailestrucke@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20180504-135054en
local.publisher.placeUnited States of Americaen
local.format.startpage1939en
local.format.endpage1944en
local.identifier.scopusid84899895665en
local.peerreviewedYesen
local.identifier.volume92en
local.identifier.issue5en
local.contributor.lastnameStruckenen
local.contributor.lastnameSchmitten
local.contributor.lastnameBergfelden
local.contributor.lastnameJurkeen
local.contributor.lastnameReissmannen
local.contributor.lastnameBrockmannen
dc.identifier.staffune-id:estruckeen
local.profile.orcid0000-0002-2715-0733en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:23139en
local.identifier.handlehttps://hdl.handle.net/1959.11/22956en
dc.identifier.academiclevelAcademicen
local.title.maintitleGenomewide study and validation of markers associated with production traits in German Landrace boars1en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorStrucken, Evaen
local.search.authorSchmitt, A Oen
local.search.authorBergfeld, Uen
local.search.authorJurke, Ien
local.search.authorReissmann, Men
local.search.authorBrockmann, G Aen
local.uneassociationUnknownen
local.year.published2014en
local.subject.for2020310509 Genomicsen
local.subject.for2020300305 Animal reproduction and breedingen
local.subject.seo2020280101 Expanding knowledge in the agricultural, food and veterinary sciencesen
local.subject.seo2020100410 Pigsen
Appears in Collections:Journal Article
School of Environmental and Rural Science
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