Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22931
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dc.contributor.authorCoumans-Moens, Joelleen
dc.contributor.authorYeoh, Thomasen
dc.contributor.authorSeeto, Reginald Ken
dc.contributor.authorKeogh, Anneen
dc.contributor.authorBrennan, Karenen
dc.contributor.authorGunning, Peteren
dc.contributor.authorHardeman, Ednaen
dc.contributor.authordos Remedios, Cristobal Gen
dc.date.accessioned2018-04-30T13:54:00Z
dc.date.issued1997en
dc.identifier.citationJournal of Molecular and Cellular Cardiology, 29(3), p. 895-905en
dc.identifier.issn1095-8584en
dc.identifier.issn0022-2828en
dc.identifier.urihttps://hdl.handle.net/1959.11/22931en
dc.description.abstractThis paper examines the quantitative relationship between the expression of myosin heavy chain (MHC) and actin at both the levels of their mRNAs and their proteins. Explanted human left ventricle tissues were obtained from non-diseased (ND) individuals and from dilated cardiomyopathy (DCM) patients with terminally failing hearts who underwent heart transplantation. We found: (1) there are substantial differences in the stoichiometry of sarcomeric MHC and actin transcripts in hearts of DCM patients as well as in ND individuals; (2) there are substantial differences between levels of total sarcomeric actin transcripts from different individual patients; (3) by and large variations in transcript levels between samples from the same heart are much less than between samples from different hearts; and (4) the ratio of MHC to sarcomeric actin proteins expressed by different ND and DCM hearts remains essentiallly constant. We conclude that the human ventricle can accomodate a substantial imbalance between sarcomeric MHC and actin mRNA levels while maintaining a constant ratio of their corresponding proteins.en
dc.languageenen
dc.publisherAcademic Pressen
dc.relation.ispartofJournal of Molecular and Cellular Cardiologyen
dc.titleVariations in the Relative mRNA Levels of Actins and Myosin Heavy Chains do not Produce Corresponding Differences in their Proteins in the Adult Human Hearten
dc.typeJournal Articleen
dc.identifier.doi10.1006/jmcc.1996.0317en
dc.subject.keywordsBiochemistry and Cell Biologyen
dc.subject.keywordsAnalytical Biochemistryen
local.contributor.firstnameJoelleen
local.contributor.firstnameThomasen
local.contributor.firstnameReginald Ken
local.contributor.firstnameAnneen
local.contributor.firstnameKarenen
local.contributor.firstnamePeteren
local.contributor.firstnameEdnaen
local.contributor.firstnameCristobal Gen
local.subject.for2008060101 Analytical Biochemistryen
local.subject.for2008060199 Biochemistry and Cell Biology not elsewhere classifieden
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.profile.schoolSchool of Rural Medicineen
local.profile.emailjmoensco@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20180428-123233en
local.publisher.placeUnited Kingdomen
local.format.startpage895en
local.format.endpage905en
local.peerreviewedYesen
local.identifier.volume29en
local.identifier.issue3en
local.contributor.lastnameCoumans-Moensen
local.contributor.lastnameYeohen
local.contributor.lastnameSeetoen
local.contributor.lastnameKeoghen
local.contributor.lastnameBrennanen
local.contributor.lastnameGunningen
local.contributor.lastnameHardemanen
local.contributor.lastnamedos Remediosen
dc.identifier.staffune-id:jmoenscoen
local.profile.orcid0000-0001-6642-5202en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
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local.identifier.unepublicationidune:23115en
local.identifier.handlehttps://hdl.handle.net/1959.11/22931en
dc.identifier.academiclevelAcademicen
local.title.maintitleVariations in the Relative mRNA Levels of Actins and Myosin Heavy Chains do not Produce Corresponding Differences in their Proteins in the Adult Human Hearten
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 3<br />Views: 15<br />Downloads: 0en
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