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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22916
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dc.contributor.authorPoulsen, Sally-Annen
dc.contributor.authorWilkinson, Brendanen
dc.contributor.authorInnocenti, Alessioen
dc.contributor.authorVullo, Danielaen
dc.contributor.authorSupuran, Claudiu Ten
dc.date.accessioned2018-04-27T15:56:00Z-
dc.date.issued2008-
dc.identifier.citationBioorganic & Medicinal Chemistry Letters, 18(16), p. 4624-4627en
dc.identifier.issn1464-3405en
dc.identifier.issn0960-894Xen
dc.identifier.urihttps://hdl.handle.net/1959.11/22916-
dc.description.abstractA library of 10 novel benzenesulfonamides containing triazole-tethered phenyl 'tail' moieties were synthesized by a Cu(I) catalyzed 1,3-dipolar cycloaddition reaction (DCR) (i.e., click chemistry) between 4-azido benzenesulfonamide and a panel of variously substituted phenyl acetylenes. These compounds were very effective inhibitors (low nanomolar) of the human mitochondrial carbonic anhydrase isozymes VA and VB. Mitochondrial carbonic anhydrases are potential targets for anti-obesity therapies, acting to reduce lipogenesis through a novel mechanism of action. The inhibitors reported here should prove valuable as lead compounds to further investigate the potential of CA inhibition for this novel therapeutic application.en
dc.languageenen
dc.publisherPergamon Pressen
dc.relation.ispartofBioorganic & Medicinal Chemistry Lettersen
dc.titleInhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivativesen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.bmcl.2008.07.010en
dc.subject.keywordsOrganic Chemical Synthesisen
dc.subject.keywordsMedicinal and Biomolecular Chemistryen
dc.subject.keywordsBiologically Active Moleculesen
local.contributor.firstnameSally-Annen
local.contributor.firstnameBrendanen
local.contributor.firstnameAlessioen
local.contributor.firstnameDanielaen
local.contributor.firstnameClaudiu Ten
local.subject.for2008030503 Organic Chemical Synthesisen
local.subject.for2008030401 Biologically Active Moleculesen
local.subject.for2008030499 Medicinal and Biomolecular Chemistry not elsewhere classifieden
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.subject.seo2008970103 Expanding Knowledge in the Chemical Sciencesen
local.subject.seo2008929999 Health not elsewhere classifieden
local.profile.schoolSchool of Science and Technologyen
local.profile.emailbwilkin7@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20180425-100547en
local.publisher.placeUnited Kingdomen
local.format.startpage4624en
local.format.endpage4627en
local.identifier.scopusid48649096568en
local.peerreviewedYesen
local.identifier.volume18en
local.identifier.issue16en
local.contributor.lastnamePoulsenen
local.contributor.lastnameWilkinsonen
local.contributor.lastnameInnocentien
local.contributor.lastnameVulloen
local.contributor.lastnameSupuranen
dc.identifier.staffune-id:bwilkin7en
local.profile.orcid0000-0003-1866-6540en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:23100en
local.identifier.handlehttps://hdl.handle.net/1959.11/22916en
dc.identifier.academiclevelAcademicen
local.title.maintitleInhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivativesen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorPoulsen, Sally-Annen
local.search.authorWilkinson, Brendanen
local.search.authorInnocenti, Alessioen
local.search.authorVullo, Danielaen
local.search.authorSupuran, Claudiu Ten
local.uneassociationUnknownen
local.year.published2008en
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