Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22382
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dc.contributor.authorPearson, Melissaen
dc.contributor.authorSmart, Neilen
dc.date.accessioned2018-01-22T11:16:00Z
dc.date.issued2018en
dc.identifier.citationHeart Failure Reviews, 23(1), p. 91-108en
dc.identifier.issn1382-4147en
dc.identifier.issn1573-7322en
dc.identifier.urihttps://hdl.handle.net/1959.11/22382en
dc.description.abstractA large body of evidence exists indicating that autonomic imbalance is characteristic of heart failure, with several parameters of autonomic function associated with adverse clinical outcomes. The aim of this systematic review and meta-analysis was to investigate the effects of exercise training on parameters of autonomic function in patients with heart failure and where possible quantify the size of the effect. We conducted database searches (PubMed, EMBASE and Cochrane Trials Register to 31 March 2017) for exercise-based rehabilitation trials in heart failure; using search terms, exercise training, autonomic function, heart rate recovery, heart rate variability and muscle sympathetic nerve activity. Pooled data indicated a statistically significant increase in heart rate recovery at 1 min (HRR1) in exercise compared to control groups, mean difference 5.90 bpm (95%CI 5.12, 6.69; p < 0.00001). Pooled data also indicated that exercise training improved the short-term heart rate variability (HRV) parameters of root mean square of successive differences between normal heart beats (RMSSD (ms)) [mean difference 10.44 (95%CI 0.60, 20.28, p = 0.04)] and high-frequency normalised units (HFnu) [mean difference 7.72 (95%CI 3.32, 12.12, p = 0.0006), which are predominantly reflective of parasympathetic activity. Analyses also indicated a statistically significant decrease in muscle sympathetic nerve activity (MSNA) bursts/minute (mean difference - 11.09 (95%CI - 16.18, - 6.00; p < 0.0001) and MSNA bursts/100 heart beats (mean difference - 15.44 (95%CI - 20.95, -9.92; p<0.00001) in exercise groups compared to controls. With improvements in HRR, HRVand MSNA, exercise training appears to facilitate an improvement in parasympathetic tone and reduction in sympathetic activity.en
dc.languageenen
dc.publisherSpringer New York LLCen
dc.relation.ispartofHeart Failure Reviewsen
dc.titleExercise therapy and autonomic function in heart failure patients: a systematic review and meta-analysisen
dc.typeJournal Articleen
dc.identifier.doi10.1007/s10741-017-9662-zen
dc.subject.keywordsExercise Physiologyen
local.contributor.firstnameMelissaen
local.contributor.firstnameNeilen
local.subject.for2008110602 Exercise Physiologyen
local.subject.seo2008920103 Cardiovascular System and Diseasesen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailmpears28@une.edu.auen
local.profile.emailnsmart2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-chute-20171211-174926en
local.publisher.placeUnited States of Americaen
local.format.startpage91en
local.format.endpage108en
local.peerreviewedYesen
local.identifier.volume23en
local.identifier.issue1en
local.title.subtitlea systematic review and meta-analysisen
local.contributor.lastnamePearsonen
local.contributor.lastnameSmarten
dc.identifier.staffune-id:mpears28en
dc.identifier.staffune-id:nsmart2en
local.profile.orcid0000-0002-8290-6409en
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:22571en
local.identifier.handlehttps://hdl.handle.net/1959.11/22382en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleExercise therapy and autonomic function in heart failure patientsen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 13<br />Views: 15<br />Downloads: 0en
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School of Science and Technology
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