Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20678
Title: Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates
Contributor(s): McDonald, David M (author); Wilkinson, Brendan (author)orcid ; Corcilius, Leo (author); Thaysen-Andersen, Morten (author); Byrne, Scott N (author); Payne, Richard J (author)
Publication Date: 2014
DOI: 10.1039/c4cc03510k
Handle Link: https://hdl.handle.net/1959.11/20678
Abstract: We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope.
Publication Type: Journal Article
Source of Publication: Chemical Communications, 50(71), p. 10273-10276
Publisher: Royal Society of Chemistry
Place of Publication: United Kingdom
ISSN: 1359-7345
1364-548X
Field of Research (FOR): 030503 Organic Chemical Synthesis
030406 Proteins and Peptides
030401 Biologically Active Molecules
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article

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