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https://hdl.handle.net/1959.11/20678| Title: | Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates | Contributor(s): | McDonald, David M (author); Wilkinson, Brendan (author) ; Corcilius, Leo (author); Thaysen-Andersen, Morten (author); Byrne, Scott N (author); Payne, Richard J (author) |
Publication Date: | 2014 | DOI: | 10.1039/c4cc03510k | Handle Link: | https://hdl.handle.net/1959.11/20678 | Abstract: | We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope. | Publication Type: | Journal Article | Source of Publication: | Chemical Communications, 50(71), p. 10273-10276 | Publisher: | Royal Society of Chemistry | Place of Publication: | United Kingdom | ISSN: | 1364-548X 1359-7345 |
Fields of Research (FoR) 2008: | 030503 Organic Chemical Synthesis 030406 Proteins and Peptides 030401 Biologically Active Molecules |
Fields of Research (FoR) 2020: | 340407 Proteins and peptides 340503 Organic chemical synthesis 340401 Biologically active molecules |
Socio-Economic Objective (SEO) 2008: | 929999 Health not elsewhere classified 970103 Expanding Knowledge in the Chemical Sciences 970106 Expanding Knowledge in the Biological Sciences |
Socio-Economic Objective (SEO) 2020: | 280105 Expanding knowledge in the chemical sciences 280102 Expanding knowledge in the biological sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article |
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