Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20674
Title: Total Synthesis of Homogeneous Antifreeze Glycopeptides and Glycoproteins
Contributor(s): Wilkinson, Brendan  (author)orcid ; Stone, Robin S (author); Capicciotti, Chantelle J (author); Thaysen-Andersen, Morten (author); Matthews, Jacqueline M (author); Packer, Nicolle H (author); Ben, Robert N (author); Payne, Richard J (author)
Publication Date: 2012
DOI: 10.1002/anie.201108682
Handle Link: https://hdl.handle.net/1959.11/20674
Abstract: Antifreeze glycoproteins (AFGPs) are a class of natural products found in deep sea teleost fish in Arctic and Antarctic waters. The physiological role of these biomolecules is to protect against cryoinjury in environments with subzero temperatures by preventing the growth of ice crystals in vivo.[¹] Structurally, AFGPs are polymeric, mucin-type glycoproteins that consist of a single glycotripeptide repeat (Ala-Thr-Ala/Pro) in which each secondary hydroxy group on threonine is linked to the disaccharide b-d-galactosyl-(1→3)- a-N-acetyl-d-galactosamine (Scheme 1).[²]
Publication Type: Journal Article
Source of Publication: Angewandte Chemie (International Edition), 51(15), p. 3606-3610
Publisher: Wiley-VCH Verlag GmbH & Co KGaA
Place of Publication: Germany
ISSN: 1521-3773
1433-7851
Fields of Research (FoR) 2008: 030406 Proteins and Peptides
030503 Organic Chemical Synthesis
030401 Biologically Active Molecules
Fields of Research (FoR) 2020: 340407 Proteins and peptides
340503 Organic chemical synthesis
340401 Biologically active molecules
Socio-Economic Objective (SEO) 2008: 970106 Expanding Knowledge in the Biological Sciences
970102 Expanding Knowledge in the Physical Sciences
970103 Expanding Knowledge in the Chemical Sciences
Socio-Economic Objective (SEO) 2020: 280102 Expanding knowledge in the biological sciences
280120 Expanding knowledge in the physical sciences
280105 Expanding knowledge in the chemical sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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