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Title: Total Synthesis of Homogeneous Antifreeze Glycopeptides and Glycoproteins
Contributor(s): Wilkinson, Brendan  (author)orcid ; Stone, Robin S (author); Capicciotti, Chantelle J (author); Thaysen-Andersen, Morten (author); Matthews, Jacqueline M (author); Packer, Nicolle H (author); Ben, Robert N (author); Payne, Richard J (author)
Publication Date: 2012
DOI: 10.1002/anie.201108682
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Abstract: Antifreeze glycoproteins (AFGPs) are a class of natural products found in deep sea teleost fish in Arctic and Antarctic waters. The physiological role of these biomolecules is to protect against cryoinjury in environments with subzero temperatures by preventing the growth of ice crystals in vivo.[¹] Structurally, AFGPs are polymeric, mucin-type glycoproteins that consist of a single glycotripeptide repeat (Ala-Thr-Ala/Pro) in which each secondary hydroxy group on threonine is linked to the disaccharide b-d-galactosyl-(1→3)- a-N-acetyl-d-galactosamine (Scheme 1).[²]
Publication Type: Journal Article
Source of Publication: Angewandte Chemie (International Edition), 51(15), p. 3606-3610
Publisher: Wiley-VCH Verlag GmbH & Co KGaA
Place of Publication: Germany
ISSN: 1433-7851
Field of Research (FOR): 030406 Proteins and Peptides
030503 Organic Chemical Synthesis
030401 Biologically Active Molecules
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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