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https://hdl.handle.net/1959.11/20674| Title: | Total Synthesis of Homogeneous Antifreeze Glycopeptides and Glycoproteins | Contributor(s): | Wilkinson, Brendan (author) ; Stone, Robin S (author); Capicciotti, Chantelle J (author); Thaysen-Andersen, Morten (author); Matthews, Jacqueline M (author); Packer, Nicolle H (author); Ben, Robert N (author); Payne, Richard J (author) |
Publication Date: | 2012 | DOI: | 10.1002/anie.201108682 | Handle Link: | https://hdl.handle.net/1959.11/20674 | Abstract: | Antifreeze glycoproteins (AFGPs) are a class of natural products found in deep sea teleost fish in Arctic and Antarctic waters. The physiological role of these biomolecules is to protect against cryoinjury in environments with subzero temperatures by preventing the growth of ice crystals in vivo.[¹] Structurally, AFGPs are polymeric, mucin-type glycoproteins that consist of a single glycotripeptide repeat (Ala-Thr-Ala/Pro) in which each secondary hydroxy group on threonine is linked to the disaccharide b-d-galactosyl-(1→3)- a-N-acetyl-d-galactosamine (Scheme 1).[²] | Publication Type: | Journal Article | Source of Publication: | Angewandte Chemie (International Edition), 51(15), p. 3606-3610 | Publisher: | Wiley-VCH Verlag GmbH & Co KGaA | Place of Publication: | Germany | ISSN: | 1521-3773 1433-7851 |
Fields of Research (FoR) 2008: | 030406 Proteins and Peptides 030503 Organic Chemical Synthesis 030401 Biologically Active Molecules |
Fields of Research (FoR) 2020: | 340407 Proteins and peptides 340503 Organic chemical synthesis 340401 Biologically active molecules |
Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences 970102 Expanding Knowledge in the Physical Sciences 970103 Expanding Knowledge in the Chemical Sciences |
Socio-Economic Objective (SEO) 2020: | 280102 Expanding knowledge in the biological sciences 280120 Expanding knowledge in the physical sciences 280105 Expanding knowledge in the chemical sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article |
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