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https://hdl.handle.net/1959.11/20009
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hu, Yingxue | en |
dc.contributor.author | Zou, Wenyue | en |
dc.contributor.author | Julita, Villy | en |
dc.contributor.author | Ramanathan, Rajesh | en |
dc.contributor.author | Tabor, Rico F | en |
dc.contributor.author | Nixon-Luke, Reece | en |
dc.contributor.author | Bryant, Gary | en |
dc.contributor.author | Bansal, Vipul | en |
dc.contributor.author | Wilkinson, Brendan | en |
dc.date.accessioned | 2017-02-16T15:23:00Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Chemical Science, 7(11), p. 6628-6634 | en |
dc.identifier.issn | 2041-6539 | en |
dc.identifier.issn | 2041-6520 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/20009 | - |
dc.description.abstract | Naturally occurring and synthetic carbohydrate amphiphiles have emerged as a promising class of antimicrobial and antiadhesive agents that act through a number of dynamic and often poorly understood mechanisms. In this paper, we provide the first report on the application of azobenzene trans-cis photoisomerization for effecting spatial and temporal control over bacterial growth and biofilm formation using carbohydrate-based surfactants. Photocontrollable surface tension studies and small angle neutron scattering (SANS) revealed the diverse geometries and dimensions of self-assemblies (micelles) made possible through variation of the head group and UV-visible light irradiation. Using these light-addressable amphiphiles, we demonstrate optical control over the antibacterial activity and formation of biofilms against multi-drug resistant (MDR) 'Pseudomonas aeruginosa', methicillin-resistant 'Staphylococcus aureus' (MRSA) and Gram-negative 'Escherichia coli'. To probe the mechanism of bioactivity further, we evaluated the impact of trans-cis photoisomerization in these surfactants on bacterial motility and revealed photomodulated enhancement in swarming motility in 'P. aeruginosa'. These light-responsive amphiphiles should attract significant interest as a new class of antibacterial agents and as investigational tools for probing the complex mechanisms underpinning bacterial adhesion and biofilm formation. | en |
dc.language | en | en |
dc.publisher | Royal Society of Chemistry | en |
dc.relation.ispartof | Chemical Science | en |
dc.title | Photomodulation of bacterial growth and biofilm formation using carbohydrate-based surfactants | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1039/c6sc03020c | en |
dcterms.accessRights | Gold | en |
dc.subject.keywords | Organic Chemical Synthesis | en |
dc.subject.keywords | Biologically Active Molecules | en |
dc.subject.keywords | Macromolecular and Materials Chemistry | en |
local.contributor.firstname | Yingxue | en |
local.contributor.firstname | Wenyue | en |
local.contributor.firstname | Villy | en |
local.contributor.firstname | Rajesh | en |
local.contributor.firstname | Rico F | en |
local.contributor.firstname | Reece | en |
local.contributor.firstname | Gary | en |
local.contributor.firstname | Vipul | en |
local.contributor.firstname | Brendan | en |
local.subject.for2008 | 030503 Organic Chemical Synthesis | en |
local.subject.for2008 | 030399 Macromolecular and Materials Chemistry not elsewhere classified | en |
local.subject.for2008 | 030401 Biologically Active Molecules | en |
local.subject.seo2008 | 929999 Health not elsewhere classified | en |
local.subject.seo2008 | 970103 Expanding Knowledge in the Chemical Sciences | en |
local.subject.seo2008 | 970106 Expanding Knowledge in the Biological Sciences | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | bwilkin7@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-chute-20161117-130849 | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 6628 | en |
local.format.endpage | 6634 | en |
local.identifier.scopusid | 84992213650 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 7 | en |
local.identifier.issue | 11 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Hu | en |
local.contributor.lastname | Zou | en |
local.contributor.lastname | Julita | en |
local.contributor.lastname | Ramanathan | en |
local.contributor.lastname | Tabor | en |
local.contributor.lastname | Nixon-Luke | en |
local.contributor.lastname | Bryant | en |
local.contributor.lastname | Bansal | en |
local.contributor.lastname | Wilkinson | en |
dc.identifier.staff | une-id:bwilkin7 | en |
local.profile.orcid | 0000-0003-1866-6540 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:20207 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Photomodulation of bacterial growth and biofilm formation using carbohydrate-based surfactants | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.relation.grantdescription | ARC/DE130101673 | en |
local.search.author | Hu, Yingxue | en |
local.search.author | Zou, Wenyue | en |
local.search.author | Julita, Villy | en |
local.search.author | Ramanathan, Rajesh | en |
local.search.author | Tabor, Rico F | en |
local.search.author | Nixon-Luke, Reece | en |
local.search.author | Bryant, Gary | en |
local.search.author | Bansal, Vipul | en |
local.search.author | Wilkinson, Brendan | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000386228900004 | en |
local.year.published | 2016 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/b40f2901-03ee-4bba-90a8-b9a9eb14c293 | en |
local.subject.for2020 | 340503 Organic chemical synthesis | en |
local.subject.for2020 | 340307 Structure and dynamics of materials | en |
local.subject.for2020 | 340401 Biologically active molecules | en |
local.subject.seo2020 | 280105 Expanding knowledge in the chemical sciences | en |
local.subject.seo2020 | 280102 Expanding knowledge in the biological sciences | en |
local.codeupdate.date | 2022-02-13T16:24:18.301 | en |
local.codeupdate.eperson | bwilkin7@une.edu.au | en |
local.codeupdate.finalised | true | en |
local.original.for2020 | undefined | en |
local.original.for2020 | 340401 Biologically active molecules | en |
local.original.for2020 | 340503 Organic chemical synthesis | en |
local.original.seo2020 | 280105 Expanding knowledge in the chemical sciences | en |
local.original.seo2020 | 280102 Expanding knowledge in the biological sciences | en |
local.original.seo2020 | undefined | en |
Appears in Collections: | Journal Article School of Science and Technology |
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