Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20009
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHu, Yingxueen
dc.contributor.authorZou, Wenyueen
dc.contributor.authorJulita, Villyen
dc.contributor.authorRamanathan, Rajeshen
dc.contributor.authorTabor, Rico Fen
dc.contributor.authorNixon-Luke, Reeceen
dc.contributor.authorBryant, Garyen
dc.contributor.authorBansal, Vipulen
dc.contributor.authorWilkinson, Brendanen
dc.date.accessioned2017-02-16T15:23:00Z-
dc.date.issued2016-
dc.identifier.citationChemical Science, 7(11), p. 6628-6634en
dc.identifier.issn2041-6539en
dc.identifier.issn2041-6520en
dc.identifier.urihttps://hdl.handle.net/1959.11/20009-
dc.description.abstractNaturally occurring and synthetic carbohydrate amphiphiles have emerged as a promising class of antimicrobial and antiadhesive agents that act through a number of dynamic and often poorly understood mechanisms. In this paper, we provide the first report on the application of azobenzene trans-cis photoisomerization for effecting spatial and temporal control over bacterial growth and biofilm formation using carbohydrate-based surfactants. Photocontrollable surface tension studies and small angle neutron scattering (SANS) revealed the diverse geometries and dimensions of self-assemblies (micelles) made possible through variation of the head group and UV-visible light irradiation. Using these light-addressable amphiphiles, we demonstrate optical control over the antibacterial activity and formation of biofilms against multi-drug resistant (MDR) 'Pseudomonas aeruginosa', methicillin-resistant 'Staphylococcus aureus' (MRSA) and Gram-negative 'Escherichia coli'. To probe the mechanism of bioactivity further, we evaluated the impact of trans-cis photoisomerization in these surfactants on bacterial motility and revealed photomodulated enhancement in swarming motility in 'P. aeruginosa'. These light-responsive amphiphiles should attract significant interest as a new class of antibacterial agents and as investigational tools for probing the complex mechanisms underpinning bacterial adhesion and biofilm formation.en
dc.languageenen
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofChemical Scienceen
dc.titlePhotomodulation of bacterial growth and biofilm formation using carbohydrate-based surfactantsen
dc.typeJournal Articleen
dc.identifier.doi10.1039/c6sc03020cen
dcterms.accessRightsGolden
dc.subject.keywordsOrganic Chemical Synthesisen
dc.subject.keywordsBiologically Active Moleculesen
dc.subject.keywordsMacromolecular and Materials Chemistryen
local.contributor.firstnameYingxueen
local.contributor.firstnameWenyueen
local.contributor.firstnameVillyen
local.contributor.firstnameRajeshen
local.contributor.firstnameRico Fen
local.contributor.firstnameReeceen
local.contributor.firstnameGaryen
local.contributor.firstnameVipulen
local.contributor.firstnameBrendanen
local.subject.for2008030503 Organic Chemical Synthesisen
local.subject.for2008030399 Macromolecular and Materials Chemistry not elsewhere classifieden
local.subject.for2008030401 Biologically Active Moleculesen
local.subject.seo2008929999 Health not elsewhere classifieden
local.subject.seo2008970103 Expanding Knowledge in the Chemical Sciencesen
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailbwilkin7@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-chute-20161117-130849en
local.publisher.placeUnited Kingdomen
local.format.startpage6628en
local.format.endpage6634en
local.identifier.scopusid84992213650en
local.peerreviewedYesen
local.identifier.volume7en
local.identifier.issue11en
local.access.fulltextYesen
local.contributor.lastnameHuen
local.contributor.lastnameZouen
local.contributor.lastnameJulitaen
local.contributor.lastnameRamanathanen
local.contributor.lastnameTaboren
local.contributor.lastnameNixon-Lukeen
local.contributor.lastnameBryanten
local.contributor.lastnameBansalen
local.contributor.lastnameWilkinsonen
dc.identifier.staffune-id:bwilkin7en
local.profile.orcid0000-0003-1866-6540en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:20207en
dc.identifier.academiclevelAcademicen
local.title.maintitlePhotomodulation of bacterial growth and biofilm formation using carbohydrate-based surfactantsen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.relation.grantdescriptionARC/DE130101673en
local.search.authorHu, Yingxueen
local.search.authorZou, Wenyueen
local.search.authorJulita, Villyen
local.search.authorRamanathan, Rajeshen
local.search.authorTabor, Rico Fen
local.search.authorNixon-Luke, Reeceen
local.search.authorBryant, Garyen
local.search.authorBansal, Vipulen
local.search.authorWilkinson, Brendanen
local.uneassociationUnknownen
local.identifier.wosid000386228900004en
local.year.published2016en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/b40f2901-03ee-4bba-90a8-b9a9eb14c293en
local.subject.for2020340503 Organic chemical synthesisen
local.subject.for2020340307 Structure and dynamics of materialsen
local.subject.for2020340401 Biologically active moleculesen
local.subject.seo2020280105 Expanding knowledge in the chemical sciencesen
local.subject.seo2020280102 Expanding knowledge in the biological sciencesen
local.codeupdate.date2022-02-13T16:24:18.301en
local.codeupdate.epersonbwilkin7@une.edu.auen
local.codeupdate.finalisedtrueen
local.original.for2020undefineden
local.original.for2020340401 Biologically active moleculesen
local.original.for2020340503 Organic chemical synthesisen
local.original.seo2020280105 Expanding knowledge in the chemical sciencesen
local.original.seo2020280102 Expanding knowledge in the biological sciencesen
local.original.seo2020undefineden
Appears in Collections:Journal Article
School of Science and Technology
Files in This Item:
2 files
File Description SizeFormat 
Show simple item record

SCOPUSTM   
Citations

42
checked on Jul 6, 2024

Page view(s)

1,348
checked on May 19, 2024
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.