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https://hdl.handle.net/1959.11/19435
Title: | Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens | Contributor(s): | Read, Andrew F (author); Baigent, Susan J (author); Powers, Claire (author); Kgosana, Lydia B (author); Blackwell, Luke (author); Smith, Lorraine P (author); Kennedy, David A (author); Walkden-Brown, Steve W (author) ; Nair, Venugopal K (author) | Publication Date: | 2015 | Open Access: | Yes | DOI: | 10.1371/journal.pbio.1002198 | Handle Link: | https://hdl.handle.net/1959.11/19435 | Abstract: | Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek's disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic strains to transmit. Immunity elicited by direct vaccination or by maternal vaccination prolongs host survival but does not prevent infection, viral replication or transmission, thus extending the infectious periods of strains otherwise too lethal to persist. Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the emergence of pathogen strains that cause more severe disease in unvaccinated hosts. | Publication Type: | Journal Article | Source of Publication: | PLoS Biology, 13(7), p. 1-18 | Publisher: | Public Library of Science | Place of Publication: | United States of America | ISSN: | 1545-7885 1544-9173 |
Fields of Research (FoR) 2008: | 070705 Veterinary Immunology 070709 Veterinary Pathology |
Fields of Research (FoR) 2020: | 300906 Veterinary immunology 300910 Veterinary pathology |
Socio-Economic Objective (SEO) 2008: | 830309 Poultry | Socio-Economic Objective (SEO) 2020: | 100411 Poultry | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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