Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/19435
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Read, Andrew F | en |
dc.contributor.author | Baigent, Susan J | en |
dc.contributor.author | Powers, Claire | en |
dc.contributor.author | Kgosana, Lydia B | en |
dc.contributor.author | Blackwell, Luke | en |
dc.contributor.author | Smith, Lorraine P | en |
dc.contributor.author | Kennedy, David A | en |
dc.contributor.author | Walkden-Brown, Steve W | en |
dc.contributor.author | Nair, Venugopal K | en |
dc.date.accessioned | 2016-08-25T11:54:00Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | PLoS Biology, 13(7), p. 1-18 | en |
dc.identifier.issn | 1545-7885 | en |
dc.identifier.issn | 1544-9173 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/19435 | - |
dc.description.abstract | Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek's disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic strains to transmit. Immunity elicited by direct vaccination or by maternal vaccination prolongs host survival but does not prevent infection, viral replication or transmission, thus extending the infectious periods of strains otherwise too lethal to persist. Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the emergence of pathogen strains that cause more severe disease in unvaccinated hosts. | en |
dc.language | en | en |
dc.publisher | Public Library of Science | en |
dc.relation.ispartof | PLoS Biology | en |
dc.title | Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1371/journal.pbio.1002198 | en |
dcterms.accessRights | Gold | en |
dc.subject.keywords | Veterinary Immunology | en |
dc.subject.keywords | Veterinary Pathology | en |
local.contributor.firstname | Andrew F | en |
local.contributor.firstname | Susan J | en |
local.contributor.firstname | Claire | en |
local.contributor.firstname | Lydia B | en |
local.contributor.firstname | Luke | en |
local.contributor.firstname | Lorraine P | en |
local.contributor.firstname | David A | en |
local.contributor.firstname | Steve W | en |
local.contributor.firstname | Venugopal K | en |
local.subject.for2008 | 070705 Veterinary Immunology | en |
local.subject.for2008 | 070709 Veterinary Pathology | en |
local.subject.seo2008 | 830309 Poultry | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.email | swalkden@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20160422-154033 | en |
local.publisher.place | United States of America | en |
local.identifier.runningnumber | e1002198 | en |
local.format.startpage | 1 | en |
local.format.endpage | 18 | en |
local.identifier.scopusid | 84938705064 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 13 | en |
local.identifier.issue | 7 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Read | en |
local.contributor.lastname | Baigent | en |
local.contributor.lastname | Powers | en |
local.contributor.lastname | Kgosana | en |
local.contributor.lastname | Blackwell | en |
local.contributor.lastname | Smith | en |
local.contributor.lastname | Kennedy | en |
local.contributor.lastname | Walkden-Brown | en |
local.contributor.lastname | Nair | en |
dc.identifier.staff | une-id:swalkden | en |
local.profile.orcid | 0000-0002-0638-5533 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:19630 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Read, Andrew F | en |
local.search.author | Baigent, Susan J | en |
local.search.author | Powers, Claire | en |
local.search.author | Kgosana, Lydia B | en |
local.search.author | Blackwell, Luke | en |
local.search.author | Smith, Lorraine P | en |
local.search.author | Kennedy, David A | en |
local.search.author | Walkden-Brown, Steve W | en |
local.search.author | Nair, Venugopal K | en |
local.uneassociation | Unknown | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.identifier.wosid | 000360617100012 | en |
local.year.published | 2015 | en |
local.subject.for2020 | 300906 Veterinary immunology | en |
local.subject.for2020 | 300910 Veterinary pathology | en |
local.subject.seo2020 | 100411 Poultry | en |
Appears in Collections: | Journal Article |
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