Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/19435
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dc.contributor.authorRead, Andrew Fen
dc.contributor.authorBaigent, Susan Jen
dc.contributor.authorPowers, Claireen
dc.contributor.authorKgosana, Lydia Ben
dc.contributor.authorBlackwell, Lukeen
dc.contributor.authorSmith, Lorraine Pen
dc.contributor.authorKennedy, David Aen
dc.contributor.authorWalkden-Brown, Steve Wen
dc.contributor.authorNair, Venugopal Ken
dc.date.accessioned2016-08-25T11:54:00Z-
dc.date.issued2015-
dc.identifier.citationPLoS Biology, 13(7), p. 1-18en
dc.identifier.issn1545-7885en
dc.identifier.issn1544-9173en
dc.identifier.urihttps://hdl.handle.net/1959.11/19435-
dc.description.abstractCould some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek's disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic strains to transmit. Immunity elicited by direct vaccination or by maternal vaccination prolongs host survival but does not prevent infection, viral replication or transmission, thus extending the infectious periods of strains otherwise too lethal to persist. Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the emergence of pathogen strains that cause more severe disease in unvaccinated hosts.en
dc.languageenen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPLoS Biologyen
dc.titleImperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogensen
dc.typeJournal Articleen
dc.identifier.doi10.1371/journal.pbio.1002198en
dcterms.accessRightsGolden
dc.subject.keywordsVeterinary Immunologyen
dc.subject.keywordsVeterinary Pathologyen
local.contributor.firstnameAndrew Fen
local.contributor.firstnameSusan Jen
local.contributor.firstnameClaireen
local.contributor.firstnameLydia Ben
local.contributor.firstnameLukeen
local.contributor.firstnameLorraine Pen
local.contributor.firstnameDavid Aen
local.contributor.firstnameSteve Wen
local.contributor.firstnameVenugopal Ken
local.subject.for2008070705 Veterinary Immunologyen
local.subject.for2008070709 Veterinary Pathologyen
local.subject.seo2008830309 Poultryen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailswalkden@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20160422-154033en
local.publisher.placeUnited States of Americaen
local.identifier.runningnumbere1002198en
local.format.startpage1en
local.format.endpage18en
local.identifier.scopusid84938705064en
local.peerreviewedYesen
local.identifier.volume13en
local.identifier.issue7en
local.access.fulltextYesen
local.contributor.lastnameReaden
local.contributor.lastnameBaigenten
local.contributor.lastnamePowersen
local.contributor.lastnameKgosanaen
local.contributor.lastnameBlackwellen
local.contributor.lastnameSmithen
local.contributor.lastnameKennedyen
local.contributor.lastnameWalkden-Brownen
local.contributor.lastnameNairen
dc.identifier.staffune-id:swalkdenen
local.profile.orcid0000-0002-0638-5533en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:19630en
dc.identifier.academiclevelAcademicen
local.title.maintitleImperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogensen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorRead, Andrew Fen
local.search.authorBaigent, Susan Jen
local.search.authorPowers, Claireen
local.search.authorKgosana, Lydia Ben
local.search.authorBlackwell, Lukeen
local.search.authorSmith, Lorraine Pen
local.search.authorKennedy, David Aen
local.search.authorWalkden-Brown, Steve Wen
local.search.authorNair, Venugopal Ken
local.uneassociationUnknownen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.identifier.wosid000360617100012en
local.year.published2015en
local.subject.for2020300906 Veterinary immunologyen
local.subject.for2020300910 Veterinary pathologyen
local.subject.seo2020100411 Poultryen
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