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https://hdl.handle.net/1959.11/18809
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DC Field | Value | Language |
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dc.contributor.author | Islam, Tanzila | en |
dc.contributor.author | Walkden-Brown, Steve W | en |
dc.contributor.author | Renz, Katrin | en |
dc.contributor.author | Islam, Afm Fakhrul | en |
dc.contributor.author | Ralapanawe, Sithara | en |
dc.date.accessioned | 2016-04-04T09:10:00Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Veterinary Microbiology, 173(3-4), p. 208-223 | en |
dc.identifier.issn | 1873-2542 | en |
dc.identifier.issn | 0378-1135 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/18809 | - |
dc.description.abstract | Vaccination is thought to contribute to an evolution in virulence of the Marek's disease virus (MDV) as vaccines prevent disease but not infection. We investigated the effects of co-infections at various intervals between Rispens/CVI988 vaccine virus (Rispens) and very virulent MDV (vvMDV) on the replication and shedding of each virus. The experiment used 600 ISA Brown layer chickens in 24 isolators with all treatments replicated in two isolators. Chickens were vaccinated with Rispens and/or challenged with the vvMDV isolate 02LAR on days 0, 5, or 10 post hatching providing vaccination to challenge intervals (VCI) of -10, -5, 0, 5 or 10 days with the negative values indicating challenge prior to vaccination. Peripheral blood lymphocytes (PBL), feathers and isolator exhaust dust were sampled between 7 and 56 days post infection (dpi) and subjected to quantitative realtime polymerase chain reaction (qPCR) to differentiate the two viruses. Overall Rispens significantly reduced the viral load of vvMDV in PBL and feather cells and shedding in dust. Similarly vvMDV significantly reduced the viral load of Rispens in PBL and feather cells but not in dust. VCI significantly influenced these relationships having strong positive and negative associations with load of vvMDV and Rispens respectively. Differences between the two viruses and their effects on each other were greatest in PBL and feathers, and least in dust. This study expands our understanding of the interaction between pathogenic and vaccinal viruses following vaccination with imperfect vaccines and has implications for selection of appropriate samples to test for vaccination success. | en |
dc.language | en | en |
dc.publisher | Elsevier BV | en |
dc.relation.ispartof | Veterinary Microbiology | en |
dc.title | Replication kinetics and shedding of very virulen Marek's disease virus and vaccinal Rispens/CV1988 virus during single and mixed infections varying in order and interval between infections | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1016/j.vetmic.2014.07.027 | en |
dc.subject.keywords | Veterinary Virology | en |
local.contributor.firstname | Tanzila | en |
local.contributor.firstname | Steve W | en |
local.contributor.firstname | Katrin | en |
local.contributor.firstname | Afm Fakhrul | en |
local.contributor.firstname | Sithara | en |
local.subject.for2008 | 070712 Veterinary Virology | en |
local.subject.seo2008 | 830309 Poultry | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.email | swalkden@une.edu.au | en |
local.profile.email | krenz@une.edu.au | en |
local.profile.email | fislam2@une.edu.au | en |
local.profile.email | sralapa2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20150327-091733 | en |
local.publisher.place | Netherlands | en |
local.format.startpage | 208 | en |
local.format.endpage | 223 | en |
local.identifier.scopusid | 84908152883 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 173 | en |
local.identifier.issue | 3-4 | en |
local.contributor.lastname | Islam | en |
local.contributor.lastname | Walkden-Brown | en |
local.contributor.lastname | Renz | en |
local.contributor.lastname | Islam | en |
local.contributor.lastname | Ralapanawe | en |
dc.identifier.staff | une-id:tislam4 | en |
dc.identifier.staff | une-id:swalkden | en |
dc.identifier.staff | une-id:krenz | en |
dc.identifier.staff | une-id:fislam2 | en |
dc.identifier.staff | une-id:sralapa2 | en |
local.profile.orcid | 0000-0002-0638-5533 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:19010 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Replication kinetics and shedding of very virulen Marek's disease virus and vaccinal Rispens/CV1988 virus during single and mixed infections varying in order and interval between infections | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Islam, Tanzila | en |
local.search.author | Walkden-Brown, Steve W | en |
local.search.author | Renz, Katrin | en |
local.search.author | Islam, Afm Fakhrul | en |
local.search.author | Ralapanawe, Sithara | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000344202900004 | en |
local.year.published | 2014 | en |
local.subject.for2020 | 300914 Veterinary virology | en |
local.subject.seo2020 | 100411 Poultry | en |
Appears in Collections: | Journal Article School of Environmental and Rural Science |
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