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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/18581
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dc.contributor.authorDenham, Joshuaen
dc.contributor.authorO'Brien, Brendan Jen
dc.contributor.authorHarvey, Jack Ten
dc.contributor.authorCharchar, Fadi Jen
dc.date.accessioned2016-02-11T14:31:00Z-
dc.date.issued2015-
dc.identifier.citationEpigenomics, 7(5), p. 717-731en
dc.identifier.issn1750-192Xen
dc.identifier.issn1750-1911en
dc.identifier.urihttps://hdl.handle.net/1959.11/18581-
dc.description.abstractAim: DNA methylation programs gene expression and is involved in numerous biological processes. Accumulating evidence supports transgenerational inheritance of DNA methylation changes in mammals via germ cells. Our aim was to determine the effect of exercise on sperm DNA methylation. Materials & methods: Twenty-four men were recruited and assigned to an exercise intervention or control group. Clinical parameters were measured and sperm samples were donated by subjects before and after the 3-month time-period. Mature sperm global and genome-wide DNA methylation was assessed using an ELISA assay and the 450K BeadChip (Illumina). Results: Global and genome-wide sperm DNA methylation was altered after 3 months of exercise training. DNA methylation changes occurred in genes related to numerous diseases such as schizophrenia and Parkinson's disease. Conclusions: Our study provides the first evidence showing exercise training reprograms the sperm methylome. Whether these DNA methylation changes are inherited to future generations warrants attention.en
dc.languageenen
dc.publisherFuture Medicine Ltden
dc.relation.ispartofEpigenomicsen
dc.titleGenome-wide sperm DNA methylation changes after 3 months of exercise training in humansen
dc.typeJournal Articleen
dc.identifier.doi10.2217/epi.15.29en
dc.subject.keywordsExercise Physiologyen
dc.subject.keywordsEpigenetics (incl. Genome Methylation and Epigenomics)en
local.contributor.firstnameJoshuaen
local.contributor.firstnameBrendan Jen
local.contributor.firstnameJack Ten
local.contributor.firstnameFadi Jen
local.subject.for2008060404 Epigenetics (incl. Genome Methylation and Epigenomics)en
local.subject.for2008110602 Exercise Physiologyen
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.subject.seo2008970111 Expanding Knowledge in the Medical and Health Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailjdenham2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20160128-075139en
local.publisher.placeUnited Kingdomen
local.format.startpage717en
local.format.endpage731en
local.peerreviewedYesen
local.identifier.volume7en
local.identifier.issue5en
local.contributor.lastnameDenhamen
local.contributor.lastnameO'Brienen
local.contributor.lastnameHarveyen
local.contributor.lastnameCharcharen
dc.identifier.staffune-id:jdenham2en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:18785en
dc.identifier.academiclevelAcademicen
local.title.maintitleGenome-wide sperm DNA methylation changes after 3 months of exercise training in humansen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorDenham, Joshuaen
local.search.authorO'Brien, Brendan Jen
local.search.authorHarvey, Jack Ten
local.search.authorCharchar, Fadi Jen
local.uneassociationUnknownen
local.year.published2015en
local.subject.for2020310504 Epigenetics (incl. genome methylation and epigenomics)en
local.subject.for2020420702 Exercise physiologyen
local.subject.seo2020280102 Expanding knowledge in the biological sciencesen
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