Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/18293
Title: | Effect of ageing and oxidative stress on antioxidant enzyme activity in different regions of the rat kidney |
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Contributor(s): | Thiab, Noor Riyadh (author); King, Nicola (author); Jones, Graham L (author) |
Publication Date: | 2015 |
DOI: | 10.1007/s11010-015-2503-2 |
Handle Link: | https://hdl.handle.net/1959.11/18293 |
Abstract: | Oxidative stress has been implicated in ageing and the pathogenesis of chronic kidney disease. We examined levels of antioxidant enzymes glutathione peroxidase, glutathione reductase, glutathione S-transferase, catalase and superoxide dismutase as modulated by age and oxidative stress in different regions of the kidney. Antioxidant enzymes were examined in different regions of the kidney in male Wistar rats. Kidneys from rats of different ages (5, 12, 36 and 60 weeks) were dissected into cortex, outer medulla and inner medulla. Tissues were incubated for 30 min with or without 0.2 mM H2O2 to induce oxidative stress. Antioxidant enzyme activities progressively decreased with age under both control and stress conditions (P |
Publication Type: | Journal Article |
Source of Publication: | Molecular and Cellular Biochemistry, 408(1-2), p. 253-260 |
Publisher: | Springer New York LLC |
Place of Publication: | United States of America |
ISSN: | 1573-4919 0300-8177 |
Fields of Research (FoR) 2008: | 060107 Enzymes 060603 Animal Physiology - Systems 119999 Medical and Health Sciences not elsewhere classified |
Fields of Research (FoR) 2020: | 310106 Enzymes 310910 Animal physiology - systems 329999 Other biomedical and clinical sciences not elsewhere classified |
Socio-Economic Objective (SEO) 2008: | 920119 Urogenital System and Disorders 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified |
Socio-Economic Objective (SEO) 2020: | 200101 Diagnosis of human diseases and conditions 200199 Clinical health not elsewhere classified |
Peer Reviewed: | Yes |
HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
Appears in Collections: | Journal Article |
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