Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/16316
Title: The effects of low- and high-dose-rate brachytherapy on depressive symptoms in prostate cancer patients
Contributor(s): Sharpley, Christopher  (author)orcid ; Christie, David R H  (author); Bitsika, Vicki  (author)orcid ; Oar, Andrew J (author)
Publication Date: 2014
DOI: 10.1007/s10147-013-0647-1
Handle Link: https://hdl.handle.net/1959.11/16316
Abstract: Objective: To compare the prevalence of depressive symptoms between prostate cancer (PCa) patients who have received low-dose rate brachytherapy (LDRB) and those receiving high-dose-rate brachytherapy (HDRB). Method: Direct comparisons were made between the prevalence of the DSM-IV-TR symptoms of major depressive disorder (MDD) based upon Zung Self-Rating Depression Scale responses and patients' records on 164 PCa patients from Queensland, Australia. Results: HDRB patients had significantly greater frequency of self-reported symptoms of crying (or feeling like it) (MDD criterion 1), and restlessness and inability to sit still (MDD criterion 5), and a nonsignificant trend towards more frequent fatigue (MDD criterion 7). There was no significant association between fatigue and having received hormone therapy. Conclusion: These three MDD symptoms, which include one of the two alternative key required symptoms (criterion 1), suggest that HDRB PCa patients may present with clinically significantly different depression profiles from their peers who receive LDRB. Treatment choices need to be focused upon possible serotonergic dysfunction as well as somatic complaints of depression. The presence of subsyndromal depression in HDRB patients also warrants consideration.
Publication Type: Journal Article
Source of Publication: International Journal of Clinical Oncology, 19(6), p. 1080-1084
Publisher: Springer Japan KK
Place of Publication: Japan
ISSN: 1437-7772
1341-9625
Fields of Research (FoR) 2008: 110901 Autonomic Nervous System
Fields of Research (FoR) 2020: 320903 Central nervous system
Socio-Economic Objective (SEO) 2008: 920111 Nervous System and Disorders
Socio-Economic Objective (SEO) 2020: 200409 Mental health
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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