Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/14395
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dc.contributor.authorFortes, M R Sen
dc.contributor.authorKemper, Ken
dc.contributor.authorZhang, Yuandanen
dc.contributor.authorHawken, R Jen
dc.contributor.authorGoddard, M Een
dc.contributor.authorLehnert, S Aen
dc.contributor.authorSasazaki, Sen
dc.contributor.authorReverter, Aen
dc.contributor.authorPryce, J Een
dc.contributor.authorBarendse, Wen
dc.contributor.authorBunch, Ren
dc.contributor.authorMcCulloch, Ren
dc.contributor.authorHarrison, Ben
dc.contributor.authorBolormaa, Sen
dc.date.accessioned2014-03-28T10:27:00Z
dc.date.issued2013en
dc.identifier.citationAnimal Genetics, 44(6), p. 636-647en
dc.identifier.issn0268-9146en
dc.identifier.issn1365-2052en
dc.identifier.urihttps://hdl.handle.net/1959.11/14395en
dc.description.abstractA putative functional mutation (rs109231213) near 'PLAG1' (BTA14) associated with stature was studied in beef cattle. Data from 8199 'Bos taurus', 'Bos indicus' and Tropical Composite cattle were used to test the associations between rs109231213 and various phenotypes. Further, 23 496 SNPs located on BTA 14 were tested for association with these phenotypes, both independently and fitted together with rs109231213. The C allele of rs109231213 significantly increased hip height, weight, net food intake, age at puberty in males and females and decreased IGF-I concentration in blood and fat depth. When rs109231213 was fitted as a fixed effect in the model, there was an overall reduction in associations between other SNPs and these traits but some SNPs remained associated (P < 10¯⁴). Frequency of the mutant 'C' allele of rs109231213 differed among 'B. indicus' (0.52), 'B. taurus' (0.96) and Tropical Composite (0.68). Most chromosomes carrying the 'C' allele had the same surrounding 10 SNP haplotype, probably because the C allele was introgressed into Brahman from 'B. taurus' cattle. A region of reduced heterozygosity surrounds the 'C' allele; this is small in B. taurus but 20Mb long in Brahmans, indicating recent and strong selection for the mutant allele. Thus, the C allele appears to mark a mutation that has been selected almost to fixation in the 'B. taurus' breeds studied here and introduced into Brahman cattle during grading up and selected to a frequency of 0.52 despite its negative effects on fertility.en
dc.languageenen
dc.publisherWiley-Blackwell Publishing Ltden
dc.relation.ispartofAnimal Geneticsen
dc.titleEvidence for pleiotropism and recent selection in the 'PLAG1' region in Australian Beef cattleen
dc.typeJournal Articleen
dc.identifier.doi10.1111/age.12075en
dc.subject.keywordsGenomicsen
dc.subject.keywordsAnimal Breedingen
local.contributor.firstnameM R Sen
local.contributor.firstnameKen
local.contributor.firstnameYuandanen
local.contributor.firstnameR Jen
local.contributor.firstnameM Een
local.contributor.firstnameS Aen
local.contributor.firstnameSen
local.contributor.firstnameAen
local.contributor.firstnameJ Een
local.contributor.firstnameWen
local.contributor.firstnameRen
local.contributor.firstnameRen
local.contributor.firstnameBen
local.contributor.firstnameSen
local.subject.for2008060408 Genomicsen
local.subject.for2008070201 Animal Breedingen
local.subject.seo2008830301 Beef Cattleen
local.profile.schoolAnimal Genetics and Breeding Uniten
local.profile.emailyzhang4@une.edu.auen
local.profile.emailSigrid.Lehnert@csiro.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20140311-144652en
local.publisher.placeUnited Kingdomen
local.format.startpage636en
local.format.endpage647en
local.peerreviewedYesen
local.identifier.volume44en
local.identifier.issue6en
local.contributor.lastnameFortesen
local.contributor.lastnameKemperen
local.contributor.lastnameZhangen
local.contributor.lastnameHawkenen
local.contributor.lastnameGoddarden
local.contributor.lastnameLehnerten
local.contributor.lastnameSasazakien
local.contributor.lastnameReverteren
local.contributor.lastnamePryceen
local.contributor.lastnameBarendseen
local.contributor.lastnameBunchen
local.contributor.lastnameMcCullochen
local.contributor.lastnameHarrisonen
local.contributor.lastnameBolormaaen
dc.identifier.staffune-id:yzhang4en
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local.identifier.unepublicationidune:14610en
local.identifier.handlehttps://hdl.handle.net/1959.11/14395en
dc.identifier.academiclevelAcademicen
local.title.maintitleEvidence for pleiotropism and recent selection in the 'PLAG1' region in Australian Beef cattleen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23909810en
local.description.statisticsepubsVisitors: 502<br />Views: 629<br />Downloads: 0en
local.search.authorFortes, M R Sen
local.search.authorKemper, Ken
local.search.authorZhang, Yuandanen
local.search.authorHawken, R Jen
local.search.authorGoddard, M Een
local.search.authorLehnert, S Aen
local.search.authorSasazaki, Sen
local.search.authorReverter, Aen
local.search.authorPryce, J Een
local.search.authorBarendse, Wen
local.search.authorBunch, Ren
local.search.authorMcCulloch, Ren
local.search.authorHarrison, Ben
local.search.authorBolormaa, Sen
Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
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