Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/14348
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dc.contributor.authorWalkden-Brown, Steve Wen
dc.contributor.authorIslam, Aminulen
dc.contributor.authorIslam, Afm Fakhrulen
dc.contributor.authorBurgess, Susanen
dc.contributor.authorGroves, Peter Johnen
dc.contributor.authorCooke, Julieen
dc.date.accessioned2014-03-24T13:47:00Z-
dc.date.issued2013-
dc.identifier.citationAustralian Veterinary Journal, 91(8), p. 341-350en
dc.identifier.issn1751-0813en
dc.identifier.issn0005-0423en
dc.identifier.urihttps://hdl.handle.net/1959.11/14348-
dc.description.abstractObjective: To pathotype Australian isolates of Marek's disease virus (MDV) in commercial broiler chickens using standard methods and to evaluate early markers of pathotype. Methods: A complete 3 x 4 factorial experiment with two replicates was conducted using 648 Cobb broiler chickens in 24 isolators. The experimental factors were vaccination (unvaccinated, herpesvirus of turkeys (HVT), bivalent (HVT + SB1 strain of serotype 2 MDV) and MDV challenge (unchallenged or 500 plaque-forming units of isolates MFP57, 02LAR or FT158). Mortality, body weight, immune-organ weights and viral load were measured to 56 days post challenge (dpc). Vaccinal protective index (PI) and virulence rank (VR) were calculated based on gross Marek's disease (MD) pathology. Results: The PIs provided by the HVT and bivalent vaccines against challenge with MPF57, 02LAR, and FT158 were 84.6% 56%, 61.4% and 82.2%, 60.8%, 57.7%, respectively, leading to putative pathotypes of virulent MDV for MPF57 and very virulent MDV for 02LAR and FT158. Significantly more of the unvaccinated chickens (85.7%) had MD lesions than chickens vaccinated with either the HVT (26.8%) or bivalent vaccine (27.6%). Strong linear relationships were observed between the incidence of MD at 56 dpc and MDV load in the spleen at 7 dpc (R² = 0.71) and MDV load in the isolator exhaust dust at 14 dpc (R² = 0.57) and 21 dpc (R² = 0.51). Immune organ weights had a weaker association with subsequent MD incidence. Conclusion: Pathotyping results in broiler chickens with maternal antibody broadly agreed with those in specific-pathogen-free chickens in other studies, with some important differences. MDV load in the spleen at 7 dpc and in isolator dust at both 14 and 21 dpc was a powerful early predictor of subsequent MD incidence.en
dc.languageenen
dc.publisherWiley-Blackwell Publishing Ltden
dc.relation.ispartofAustralian Veterinary Journalen
dc.titlePathotyping of Australian isolates of Marek's disease virus in commercial broiler chickens vaccinated with herpesvirus of turkeys (HVT) or bivalent (HVT/SB1) vaccine and associated with viral load in the spleen and feather danderen
dc.typeJournal Articleen
dc.identifier.doi10.1111/avj.12084en
dc.subject.keywordsVeterinary Virologyen
local.contributor.firstnameSteve Wen
local.contributor.firstnameAminulen
local.contributor.firstnameAfm Fakhrulen
local.contributor.firstnameSusanen
local.contributor.firstnamePeter Johnen
local.contributor.firstnameJulieen
local.subject.for2008070712 Veterinary Virologyen
local.subject.seo2008830309 Poultryen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailswalkden@une.edu.auen
local.profile.emailfislam2@une.edu.auen
local.profile.emailsburgess@une.edu.auen
local.profile.emailpgroves2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20140115-092353en
local.publisher.placeUnited Kingdomen
local.format.startpage341en
local.format.endpage350en
local.identifier.scopusid84874718871en
local.peerreviewedYesen
local.identifier.volume91en
local.identifier.issue8en
local.contributor.lastnameWalkden-Brownen
local.contributor.lastnameIslamen
local.contributor.lastnameIslamen
local.contributor.lastnameBurgessen
local.contributor.lastnameGrovesen
local.contributor.lastnameCookeen
dc.identifier.staffune-id:swalkdenen
dc.identifier.staffune-id:aislam5en
dc.identifier.staffune-id:fislam2en
dc.identifier.staffune-id:sburgessen
dc.identifier.staffune-id:pgroves2en
local.profile.orcid0000-0002-0638-5533en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:14563en
local.identifier.handlehttps://hdl.handle.net/1959.11/14348en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelStudenten
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitlePathotyping of Australian isolates of Marek's disease virus in commercial broiler chickens vaccinated with herpesvirus of turkeys (HVT) or bivalent (HVT/SB1) vaccine and associated with viral load in the spleen and feather danderen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorWalkden-Brown, Steve Wen
local.search.authorIslam, Aminulen
local.search.authorIslam, Afm Fakhrulen
local.search.authorBurgess, Susanen
local.search.authorGroves, Peter Johnen
local.search.authorCooke, Julieen
local.uneassociationYesen
local.identifier.wosid000330239000028en
local.year.published2013-
local.subject.for2020300914 Veterinary virologyen
local.subject.seo2020100411 Poultryen
Appears in Collections:Journal Article
School of Environmental and Rural Science
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