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https://hdl.handle.net/1959.11/12031| Title: | Fluorescent Angiotensin AT₁ Receptor Antagonists | Contributor(s): | Giarrusso, Marilena A (author); Taylor, Michelle K (author); Ziogas, James (author); Brody, Kate M (author); Macdougall, Phoebe E (author); Schiesser, Carl H (author) | Publication Date: | 2012 | DOI: | 10.1002/ajoc.201200064 | Handle Link: | https://hdl.handle.net/1959.11/12031 | Abstract: | Fluorescent selective angiotensin AT₁ receptor antagonists (sartans) that contain naphthalene (6, 7, 10, and 11), anthracene (12 and 14), acenaphthene (13 and 15), and coumarin (8 and 9) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary (CHO) cell based assays. Compounds 6-15 proved to be effective sartans with pKB estimates in the range of 6.7-10.5; their potential as cellular imaging agents is also discussed. | Publication Type: | Journal Article | Source of Publication: | Asian Journal of Organic Chemistry, 1(3), p. 274-279 | Publisher: | Wiley-VCH Verlag GmbH & Co KGaA | Place of Publication: | Germany | ISSN: | 2193-5815 2193-5807 |
Fields of Research (FoR) 2008: | 030401 Biologically Active Molecules 030503 Organic Chemical Synthesis |
Fields of Research (FoR) 2020: | 340401 Biologically active molecules 340503 Organic chemical synthesis |
Socio-Economic Objective (SEO) 2008: | 970103 Expanding Knowledge in the Chemical Sciences | Socio-Economic Objective (SEO) 2020: | 280105 Expanding knowledge in the chemical sciences | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article |
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