Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/12031
Title: Fluorescent Angiotensin AT₁ Receptor Antagonists
Contributor(s): Giarrusso, Marilena A (author); Taylor, Michelle K (author); Ziogas, James (author); Brody, Kate M (author); Macdougall, Phoebe E (author); Schiesser, Carl H (author)
Publication Date: 2012
DOI: 10.1002/ajoc.201200064
Handle Link: https://hdl.handle.net/1959.11/12031
Abstract: Fluorescent selective angiotensin AT₁ receptor antagonists (sartans) that contain naphthalene (6, 7, 10, and 11), anthracene (12 and 14), acenaphthene (13 and 15), and coumarin (8 and 9) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary (CHO) cell based assays. Compounds 6-15 proved to be effective sartans with pKB estimates in the range of 6.7-10.5; their potential as cellular imaging agents is also discussed.
Publication Type: Journal Article
Source of Publication: Asian Journal of Organic Chemistry, 1(3), p. 274-279
Publisher: Wiley-VCH Verlag GmbH & Co KGaA
Place of Publication: Germany
ISSN: 2193-5815
2193-5807
Field of Research (FOR): 030401 Biologically Active Molecules
030503 Organic Chemical Synthesis
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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