Title
Novel endoperoxides: Synthesis and activity against 'Candida' species
Author(s)
Date Issued
2006
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Research Output Type
Journal Article
HERDC Category
Abstract
Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic 'Candida' species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against 'Candida' growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.
Source
Bioorganic & Medicinal Chemistry Letters, 16(4), p. 920-922
Publisher
Pergamon Press
Place of Publication
United Kingdom
ISSN
1464-3405
0960-894X
Keywords
Biologically Active Molecules
Organic Chemical Synthesis
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