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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/9027
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dc.contributor.authorBehnke, JMen
dc.contributor.authorMenge, DMen
dc.contributor.authorNagda, Sen
dc.contributor.authorNoyes, Hen
dc.contributor.authorIraqi, FAen
dc.contributor.authorKemp, SJen
dc.contributor.authorMugambi, RJMen
dc.contributor.authorBaker, RLen
dc.contributor.authorWakelin, Den
dc.contributor.authorGibson, Johnen
dc.date.accessioned2011-12-12T14:29:00Z-
dc.date.issued2010-
dc.identifier.citationParasitology, 137(2), p. 311-320en
dc.identifier.issn1469-8161en
dc.identifier.issn0031-1820en
dc.identifier.urihttps://hdl.handle.net/1959.11/9027-
dc.description.abstractA comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to 'Heligmosomoides bakeri'. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to 'H. bakeri' is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.en
dc.languageenen
dc.publisherCambridge University Pressen
dc.relation.ispartofParasitologyen
dc.titleQuantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of miceen
dc.typeJournal Articleen
dc.identifier.doi10.1017/S0031182009991028en
dc.subject.keywordsGenetic Immunologyen
local.contributor.firstnameJMen
local.contributor.firstnameDMen
local.contributor.firstnameSen
local.contributor.firstnameHen
local.contributor.firstnameFAen
local.contributor.firstnameSJen
local.contributor.firstnameRJMen
local.contributor.firstnameRLen
local.contributor.firstnameDen
local.contributor.firstnameJohnen
local.subject.for2008060406 Genetic Immunologyen
local.subject.seo2008830399 Livestock Raising not elsewhere classifieden
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailjgibson5@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20111205-121343en
local.publisher.placeUnited Kingdomen
local.format.startpage311en
local.format.endpage320en
local.peerreviewedYesen
local.identifier.volume137en
local.identifier.issue2en
local.title.subtitlecomparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of miceen
local.contributor.lastnameBehnkeen
local.contributor.lastnameMengeen
local.contributor.lastnameNagdaen
local.contributor.lastnameNoyesen
local.contributor.lastnameIraqien
local.contributor.lastnameKempen
local.contributor.lastnameMugambien
local.contributor.lastnameBakeren
local.contributor.lastnameWakelinen
local.contributor.lastnameGibsonen
dc.identifier.staffune-id:jgibson5en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:9217en
dc.identifier.academiclevelAcademicen
local.title.maintitleQuantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in miceen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorBehnke, JMen
local.search.authorMenge, DMen
local.search.authorNagda, Sen
local.search.authorNoyes, Hen
local.search.authorIraqi, FAen
local.search.authorKemp, SJen
local.search.authorMugambi, RJMen
local.search.authorBaker, RLen
local.search.authorWakelin, Den
local.search.authorGibson, Johnen
local.uneassociationUnknownen
local.year.published2010en
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