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https://hdl.handle.net/1959.11/8319
Title: | Long chain omega-3 polyunsaturated fatty acids in the treatment of psychiatric illnesses in children and adolescents | Contributor(s): | Clayton, EH (author); Hanstock, Tanya (author); Garg, ML (author); Hazell, PL (author) | Publication Date: | 2007 | DOI: | 10.1111/j.1601-5215.2007.00189.x | Handle Link: | https://hdl.handle.net/1959.11/8319 | Abstract: | Objective: Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adolescents. Methods: A search of Psychlit, PubMed and Cochrane Databases was conducted using the terms child, adolescent, bipolar, depression, psychosis, first-episode psychosis, schizophrenia, attention deficit hyperactivity disorder (ADHD), autism, psychiatric, omega-3, n-3, docosahexaenoic acid and eicosapentaenoic acid. Further studies were identified from the bibliographies of published reviews. Results: One small randomized controlled trial with LCn-3PUFA supplementation in depression in children found a small beneficial effect over placebo. Four placebo-controlled trials showed uncertain benefit of LCn-3PUFA for ADHD. Single placebo-controlled trials showed no benefit in autism or bipolar disorder. There is an absence of studies examining benefit for first-episode psychosis or schizophrenia in children and adolescents. Conclusions: While children and adolescents are receiving LCn-3PUFA for a range of psychiatric indications, there is only evidence of likely benefit for unipolar depression. | Publication Type: | Journal Article | Source of Publication: | Acta Neuropsychiatrica, 19(2), p. 92-103 | Publisher: | Blackwell Munksgaard | Place of Publication: | United States of America | ISSN: | 1601-5215 0924-2708 |
Fields of Research (FoR) 2008: | 170106 Health, Clinical and Counselling Psychology | Socio-Economic Objective (SEO) 2008: | 920410 Mental Health 920411 Nutrition |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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