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https://hdl.handle.net/1959.11/7539
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DC Field | Value | Language |
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dc.contributor.author | Staples, Maree K | en |
dc.contributor.author | Grange, Rebecca L | en |
dc.contributor.author | Angus, James A | en |
dc.contributor.author | Ziogas, James | en |
dc.contributor.author | Tan, Nichole P H | en |
dc.contributor.author | Taylor, Michelle Keily | en |
dc.contributor.author | Schiesser, Carl H | en |
dc.date.accessioned | 2011-05-25T10:31:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Organic & Biomolecular Chemistry, 9(2), p. 473-479 | en |
dc.identifier.issn | 1477-0539 | en |
dc.identifier.issn | 1477-0520 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/7539 | - |
dc.description.abstract | Benzothiophene and benzoselenophene analogues of the thiophene-containing antihypertensives milfasartan and eprosartan were prepared and tested for AT1 receptor antagonist properties. While the sulfur-containing systems were prepared following existing methodology, the selenium-containing analogues required the development of novel, tandem free-radical chemistry involving addition of aryl radicals to alkynes, followed by intramolecular homolytic substitution at the higher heteroatom. All four compounds prepared proved to be excellent AT₁ receptor antagonists, with pKв estimates of 7.2-9.5. | en |
dc.language | en | en |
dc.publisher | Royal Society of Chemistry | en |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en |
dc.title | Tandem free-radical addition/substitution chemistry and its application to the preparation of novel AT₁ receptor antagonists | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1039/c0ob00573h | en |
dc.subject.keywords | Biologically Active Molecules | en |
dc.subject.keywords | Organic Chemical Synthesis | en |
dc.subject.keywords | Free Radical Chemistry | en |
local.contributor.firstname | Maree K | en |
local.contributor.firstname | Rebecca L | en |
local.contributor.firstname | James A | en |
local.contributor.firstname | James | en |
local.contributor.firstname | Nichole P H | en |
local.contributor.firstname | Michelle Keily | en |
local.contributor.firstname | Carl H | en |
local.subject.for2008 | 030501 Free Radical Chemistry | en |
local.subject.for2008 | 030503 Organic Chemical Synthesis | en |
local.subject.for2008 | 030401 Biologically Active Molecules | en |
local.subject.seo2008 | 970103 Expanding Knowledge in the Chemical Sciences | en |
local.profile.school | Chemistry | en |
local.profile.school | Chemistry | en |
local.profile.school | Chemistry | en |
local.profile.school | Chemistry | en |
local.profile.school | Chemistry | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | Chemistry | en |
local.profile.email | mtaylo53@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20110323-170720 | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 473 | en |
local.format.endpage | 479 | en |
local.identifier.scopusid | 78650727564 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 9 | en |
local.identifier.issue | 2 | en |
local.contributor.lastname | Staples | en |
local.contributor.lastname | Grange | en |
local.contributor.lastname | Angus | en |
local.contributor.lastname | Ziogas | en |
local.contributor.lastname | Tan | en |
local.contributor.lastname | Taylor | en |
local.contributor.lastname | Schiesser | en |
dc.identifier.staff | une-id:mtaylo53 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:7707 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Tandem free-radical addition/substitution chemistry and its application to the preparation of novel AT₁ receptor antagonists | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Staples, Maree K | en |
local.search.author | Grange, Rebecca L | en |
local.search.author | Angus, James A | en |
local.search.author | Ziogas, James | en |
local.search.author | Tan, Nichole P H | en |
local.search.author | Taylor, Michelle Keily | en |
local.search.author | Schiesser, Carl H | en |
local.uneassociation | Unknown | en |
local.year.published | 2011 | en |
Appears in Collections: | Journal Article |
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