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https://hdl.handle.net/1959.11/7473
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DC Field | Value | Language |
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dc.contributor.author | Hanstock, Tanya | en |
dc.contributor.author | Mallet, Paul E | en |
dc.contributor.author | Clayton, EH | en |
dc.date.accessioned | 2011-05-19T10:17:00Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Physiology & Behavior, 101(5), p. 653-659 | en |
dc.identifier.issn | 1873-507X | en |
dc.identifier.issn | 0031-9384 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/7473 | - |
dc.description.abstract | Aim: ᴅ-Lactic acidosis is associated with memory impairment in humans. Recent research indicates that ᴅ-lactic acid may inhibit the supply of energy from astrocytes to neurons involved with memory formation. However, little is known about the effects of increased hind-gut fermentation due to changes in diet on circulating lactic acid concentrations and memory. Method: Thirty-six male Wistar rats were fed three dietary treatments: a commercial rat and mouse chow, a soluble carbohydrate based diet or a fermentable carbohydrate based diet. The parameters estimating memory were examined by employing the object recognition test. Physical parameters of fermentation including hind-gut and plasma lactic acid concentrations were examined after sacrifice, either 3 or 21 h after feeding. Results: Increased fermentation in the hind-gut of rats, indicated by lower caecum pH, was associated with increased plasma L-lactic acid (r=-0.41, p=0.020) and ᴅ-lactic acid (r=-0.33, p=0.087). Memory, being able to discriminate between a familiar and a novel object during the object recognition test, was reduced with increasing plasma ᴅ-lactic acid (r=−0.51, p=0.021). Conclusions: Memory impairment was associated with alterations in plasma ᴅ-lactic acid following the fermentation of carbohydrate in the hind-gut. Further work is still required to determine whether these effects are mediated centrally or via direct connections through the enteric nervous system. | en |
dc.language | en | en |
dc.publisher | Elsevier Inc | en |
dc.relation.ispartof | Physiology & Behavior | en |
dc.title | Increased plasma ᴅ-lactic acid associated with impaired memory in rats | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1016/j.physbeh.2010.09.018 | en |
dc.subject.keywords | Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) | en |
local.contributor.firstname | Tanya | en |
local.contributor.firstname | Paul E | en |
local.contributor.firstname | EH | en |
local.subject.for2008 | 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) | en |
local.subject.seo2008 | 920401 Behaviour and Health | en |
local.profile.school | Psychology | en |
local.profile.school | Psychology | en |
local.profile.school | Psychology | en |
local.profile.email | thansto2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20110331-121032 | en |
local.publisher.place | United States of America | en |
local.format.startpage | 653 | en |
local.format.endpage | 659 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 101 | en |
local.identifier.issue | 5 | en |
local.contributor.lastname | Hanstock | en |
local.contributor.lastname | Mallet | en |
local.contributor.lastname | Clayton | en |
dc.identifier.staff | une-id:thansto2 | en |
dc.identifier.staff | une-id:pmallet | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:7641 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Increased plasma ᴅ-lactic acid associated with impaired memory in rats | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Hanstock, Tanya | en |
local.search.author | Mallet, Paul E | en |
local.search.author | Clayton, EH | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000285126300016 | en |
local.year.published | 2010 | en |
Appears in Collections: | Journal Article |
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