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https://hdl.handle.net/1959.11/69
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Banks, T | en |
dc.contributor.author | Bonin, A | en |
dc.contributor.author | Glover, S | en |
dc.contributor.author | Prakash, A | en |
dc.date.accessioned | 2008-05-02T14:24:00Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Organic & Biomolecular Chemistry, 1(13), p. 2238-2246 | en |
dc.identifier.issn | 1477-0539 | en |
dc.identifier.issn | 1477-0520 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/69 | - |
dc.description.abstract | N-Acyloxy-N-alkoxyamides are anomeric amides that are direct-acting mutagens. They have been shown to damage DNA in the major and the minor grooves in a pH and sequence-selective manner. In acidic media, they damage adenines at N3 in the minor groove but above neutral pH, only guanine is damaged at N7 in the major groove. Both the acyloxy leaving group and the alkoxy group at the amide nitrogen are responsible for their electrophilicity and Salmonella mutagenicities in TA100 and DNA damage data confirm that the mutagens react with DNA in an intact form, rather than by solvolysis to electrophilic nitrenium ions in the cytosol, or in vitro, prior to reacting with DNA. Hydrophobicity plays a role in both mutagenicity and DNA damage. | en |
dc.language | en | en |
dc.publisher | Royal Society of Chemistry | en |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en |
dc.title | Mutagenicity and DNA damage studies of N-acyloxy-N-alkoxyamides: the role of electrophilic nitrogen | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1039/b301618h | en |
dc.subject.keywords | Medicinal and Biomolecular Chemistry | en |
local.contributor.firstname | T | en |
local.contributor.firstname | A | en |
local.contributor.firstname | S | en |
local.contributor.firstname | A | en |
local.subject.for2008 | 030499 Medicinal and Biomolecular Chemistry not elsewhere classified | en |
local.subject.seo | 780103 Chemical sciences | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | sglover@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | pes:675 | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 2238 | en |
local.format.endpage | 2246 | en |
local.identifier.scopusid | 0041806645 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 1 | en |
local.identifier.issue | 13 | en |
local.title.subtitle | the role of electrophilic nitrogen | en |
local.contributor.lastname | Banks | en |
local.contributor.lastname | Bonin | en |
local.contributor.lastname | Glover | en |
local.contributor.lastname | Prakash | en |
dc.identifier.staff | une-id:tbanks3 | en |
dc.identifier.staff | une-id:sglover | en |
local.profile.orcid | 0000-0002-9344-8669 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:68 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Mutagenicity and DNA damage studies of N-acyloxy-N-alkoxyamides | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Banks, T | en |
local.search.author | Bonin, A | en |
local.search.author | Glover, S | en |
local.search.author | Prakash, A | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000183775100006 | en |
local.year.published | 2003 | en |
Appears in Collections: | Journal Article |
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