Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/6717
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dc.contributor.authorHine, BCen
dc.contributor.authorHunt, PWen
dc.contributor.authorBeasley, AMen
dc.contributor.authorWindon, RGen
dc.contributor.authorGlover, Stephenen
dc.contributor.authorColditz, Ianen
dc.date.accessioned2010-10-15T10:11:00Z-
dc.date.issued2010-
dc.identifier.citationResearch in Veterinary Science, 89(2), p. 184-190en
dc.identifier.issn1532-2661en
dc.identifier.issn0034-5288en
dc.identifier.urihttps://hdl.handle.net/1959.11/6717-
dc.description.abstractImmunoglobulin (Ig) E is actively transported into ovine colostrum. Here we examine the degree of selectivity and the mechanism by which this transfer occurs in sheep. Results indicate that during colostrogenesis in sheep, transfer of immunoglobulins was most selective for IgG1 and IgA followed by IgE, IgM and IgG2. In milk, selectivity was greatest for IgA, followed by IgM, IgE, IgG1 and IgG2. The neonatal Fc receptor (FcRn) and poly immunoglobulin receptor (pIgR) mediate the transport of IgG1 and IgA across the ovine mammary epithelium respectively. In primates and rodents, the low-affinity IgE receptor, FcεRII, functions to transport IgE across the intestinal epithelium. We therefore investigated the expression of the low-affinity IgE receptor (CD23), pIgR and FcRn transcripts in the ovine mammary gland. The expression profiles of FcRn, pIgR and CD23 mRNA reflected concentrations of their Ig ligands in mammary secretions. These findings suggest a role for CD23 in transport of IgE across the mammary epithelium of sheep.en
dc.languageenen
dc.publisherElsevier Ltden
dc.relation.ispartofResearch in Veterinary Scienceen
dc.titleSelective transport of IgE into ovine mammary secretionsen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.rvsc.2010.02.010en
dc.subject.keywordsReceptors and Membrane Biologyen
dc.subject.keywordsAnimal Physiology - Cellen
dc.subject.keywordsVeterinary Immunologyen
local.contributor.firstnameBCen
local.contributor.firstnamePWen
local.contributor.firstnameAMen
local.contributor.firstnameRGen
local.contributor.firstnameStephenen
local.contributor.firstnameIanen
local.subject.for2008060602 Animal Physiology - Cellen
local.subject.for2008060110 Receptors and Membrane Biologyen
local.subject.for2008070705 Veterinary Immunologyen
local.subject.seo2008830507 Unprocessed or Minimally Processed Milken
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailbrad.hine@agresearch.co.nzen
local.profile.emailsglover@une.edu.auen
local.profile.emailicoldit2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20101011-163321en
local.publisher.placeUnited Kingdomen
local.format.startpage184en
local.format.endpage190en
local.identifier.scopusid77955920965en
local.peerreviewedYesen
local.identifier.volume89en
local.identifier.issue2en
local.contributor.lastnameHineen
local.contributor.lastnameHunten
local.contributor.lastnameBeasleyen
local.contributor.lastnameWindonen
local.contributor.lastnameGloveren
local.contributor.lastnameColditzen
dc.identifier.staffune-id:sgloveren
dc.identifier.staffune-id:icoldit2en
local.profile.orcid0000-0002-9344-8669en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:6877en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleSelective transport of IgE into ovine mammary secretionsen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorHine, BCen
local.search.authorHunt, PWen
local.search.authorBeasley, AMen
local.search.authorWindon, RGen
local.search.authorGlover, Stephenen
local.search.authorColditz, Ianen
local.uneassociationUnknownen
local.identifier.wosid000282120400009en
local.year.published2010en
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