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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/61227
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dc.contributor.authorWong, Jin-Yingen
dc.contributor.authorYin Ng, Zhaoen
dc.contributor.authorMehta, Meenuen
dc.contributor.authorDhar Shukla, Shaktien
dc.contributor.authorPanneerselvam, Jithendraen
dc.contributor.authorMadheswaran, Thiagarajanen
dc.contributor.authorGupta, Gauraven
dc.contributor.authorNegi, Poonamen
dc.contributor.authorKumar, Pradeepen
dc.contributor.authorPillay, Vinessen
dc.contributor.authorHsu, Alanen
dc.contributor.authorHansbro, Nicole Gen
dc.contributor.authorWark, Peteren
dc.contributor.authorBebawy, Maryen
dc.contributor.authorHansbro, Philip Michaelen
dc.contributor.authorDua, Kamalen
dc.contributor.authorKumar Chellappan, Dineshen
dc.date.accessioned2024-07-05T08:44:59Z-
dc.date.available2024-07-05T08:44:59Z-
dc.date.issued2020-
dc.identifier.citationNanomedicine, 15(30), p. 2955-2970en
dc.identifier.issn1748-6963en
dc.identifier.issn1743-5889en
dc.identifier.urihttps://hdl.handle.net/1959.11/61227-
dc.description.abstract<p><b>Aim:</b> In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma. <b>Materials & methods:</b> The formulation underwent various physicochemical characterization experiments, an in vitro release study, molecular simulations and was evaluated for in vitro anti-inflammatory activity. <b>Results:</b> Results showed that Nio-Curc had a mean particle size of 284.93 ± 14.27 nm, zeta potential of -46.93 and encapsulation efficacy of 99.62%, which demonstrates optimized physicochemical characteristics. Curcumin release in vitro could be sustained for up to 24 h. Additionally, Nio-Curc effectively reduced mRNA transcript expression of pro-inflammatory markers; IL-6, IL-8, IL-1β and TNF-α in immortalized human airway basal cell line (BCi-NS1.1). <b>Conclusion:</b> In this study, we have demonstrated that Nio-Curc mitigated the mRNA expression of pro-inflammatory markers in an in vitro study, which could be applied to treatment of asthma with further studies.</p>en
dc.languageenen
dc.publisherFuture Medicine Ltden
dc.relation.ispartofNanomedicineen
dc.titleCurcumin-Loaded Niosomes Downregulate mRNA Expression of Pro-Inflammatory Markers Involved in Asthma: An In Vitro Studyen
dc.typeJournal Articleen
dc.identifier.doi10.2217/nnm-2020-0260en
local.contributor.firstnameJin-Yingen
local.contributor.firstnameZhaoen
local.contributor.firstnameMeenuen
local.contributor.firstnameShaktien
local.contributor.firstnameJithendraen
local.contributor.firstnameThiagarajanen
local.contributor.firstnameGauraven
local.contributor.firstnamePoonamen
local.contributor.firstnamePradeepen
local.contributor.firstnameVinessen
local.contributor.firstnameAlanen
local.contributor.firstnameNicole Gen
local.contributor.firstnamePeteren
local.contributor.firstnameMaryen
local.contributor.firstnamePhilip Michaelen
local.contributor.firstnameKamalen
local.contributor.firstnameDineshen
local.profile.schoolSchool of Psychologyen
local.profile.emailmbebawy@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited Kingdomen
local.format.startpage2955en
local.format.endpage2970en
local.peerreviewedYesen
local.identifier.volume15en
local.identifier.issue30en
local.title.subtitleAn In Vitro Studyen
local.contributor.lastnameWongen
local.contributor.lastnameYin Ngen
local.contributor.lastnameMehtaen
local.contributor.lastnameDhar Shuklaen
local.contributor.lastnamePanneerselvamen
local.contributor.lastnameMadheswaranen
local.contributor.lastnameGuptaen
local.contributor.lastnameNegien
local.contributor.lastnameKumaren
local.contributor.lastnamePillayen
local.contributor.lastnameHsuen
local.contributor.lastnameHansbroen
local.contributor.lastnameWarken
local.contributor.lastnameBebawyen
local.contributor.lastnameHansbroen
local.contributor.lastnameDuaen
local.contributor.lastnameKumar Chellappanen
dc.identifier.staffune-id:mbebawyen
local.profile.orcid0000-0003-2606-921Xen
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local.identifier.unepublicationidune:1959.11/61227en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
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dc.identifier.academiclevelAcademicen
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dc.identifier.academiclevelAcademicen
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dc.identifier.academiclevelAcademicen
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dc.identifier.academiclevelAcademicen
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local.title.maintitleCurcumin-Loaded Niosomes Downregulate mRNA Expression of Pro-Inflammatory Markers Involved in Asthmaen
local.relation.fundingsourcenoteThis research was supported by a grant from the International Medical University (IMU), Malaysia (ID No.: BPI-01/14(30)2017). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorWong, Jin-Yingen
local.search.authorYin Ng, Zhaoen
local.search.authorMehta, Meenuen
local.search.authorDhar Shukla, Shaktien
local.search.authorPanneerselvam, Jithendraen
local.search.authorMadheswaran, Thiagarajanen
local.search.authorGupta, Gauraven
local.search.authorNegi, Poonamen
local.search.authorKumar, Pradeepen
local.search.authorPillay, Vinessen
local.search.authorHsu, Alanen
local.search.authorHansbro, Nicole Gen
local.search.authorWark, Peteren
local.search.authorBebawy, Maryen
local.search.authorHansbro, Philip Michaelen
local.search.authorDua, Kamalen
local.search.authorKumar Chellappan, Dineshen
local.uneassociationNoen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.year.published2020en
local.subject.for20203208 Medical physiologyen
local.profile.affiliationtypeExternal Affiliationen
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local.profile.affiliationtypeExternal Affiliationen
local.date.moved2024-07-19en
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