Colonic oncostatin M expression evaluated by immunohistochemistry and infliximab therapy outcome in corticosteroid-refractory acute severe ulcerative colitis

O’Connell, Jim; Doherty, Jayne; Buckley, Amy; Cormican, David; Dunne, Cara; Hartery, Karen; Larkin, John; MacCarthy, Finbar; McCormick, Paul; McKiernan, Susan; Mehigan, Brian; Muldoon, Cian; Ryan, Ciara; O’Sullivan, Jacintha; Kevans, David

Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/61207

Full metadata record

DC Field	Value	Language
dc.contributor.author	O’Connell, Jim	en
dc.contributor.author	Doherty, Jayne	en
dc.contributor.author	Buckley, Amy	en
dc.contributor.author	Cormican, David	en
dc.contributor.author	Dunne, Cara	en
dc.contributor.author	Hartery, Karen	en
dc.contributor.author	Larkin, John	en
dc.contributor.author	MacCarthy, Finbar	en
dc.contributor.author	McCormick, Paul	en
dc.contributor.author	McKiernan, Susan	en
dc.contributor.author	Mehigan, Brian	en
dc.contributor.author	Muldoon, Cian	en
dc.contributor.author	Ryan, Ciara	en
dc.contributor.author	O’Sullivan, Jacintha	en
dc.contributor.author	Kevans, David	en
dc.date.accessioned	2024-07-05T06:17:34Z	-
dc.date.available	2024-07-05T06:17:34Z	-
dc.date.issued	2022	-
dc.identifier.citation	Intestinal Research, 20(3), p. 381-385	en
dc.identifier.issn	2288-1956	en
dc.identifier.issn	1598-9100	en
dc.identifier.uri	https://hdl.handle.net/1959.11/61207	-
dc.description.abstract	<p>Ulcerative colitis (UC) is a chronic relapsing remitting inflammatory disease of the colon. The lifetime risk of presentation with acute severe ulcerative colitis (ASUC) is 15%.<sup>1</sup> Patients with ASUC receive first line therapy with intravenous corticosteroids, however, approximately 30% have corticosteroid-refractory disease.<sup>2</sup>,3 In this situation, rescue medical therapy options include the anti-tumor necrosis factor (TNF) monoclonal antibody infliximab (IFX) or the calcineurin inhibitor ciclosporin.<sup>2</sup> A significant proportion of patients fail to respond to IFX therapy with reported colectomy rates at 1 year of 35%.<sup>4</sup> Biomarkers which identify patients with corticosteroid-refractory ASUC, with a reduced likelihood of IFX response, would significantly advance clinical care for these patients.</p>	en
dc.language	en	en
dc.publisher	Korean Association for the Study of Intestinal Diseases,Daehan Jang Yeon'gu Haghoe	en
dc.relation.ispartof	Intestinal Research	en
dc.rights	Attribution-NonCommercial 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	*
dc.title	Colonic oncostatin M expression evaluated by immunohistochemistry and infliximab therapy outcome in corticosteroid-refractory acute severe ulcerative colitis	en
dc.type	Journal Article	en
dc.identifier.doi	10.5217/ir.2021.00073	en
dcterms.accessRights	UNE Green	en
local.contributor.firstname	Jim	en
local.contributor.firstname	Jayne	en
local.contributor.firstname	Amy	en
local.contributor.firstname	David	en
local.contributor.firstname	Cara	en
local.contributor.firstname	Karen	en
local.contributor.firstname	John	en
local.contributor.firstname	Finbar	en
local.contributor.firstname	Paul	en
local.contributor.firstname	Susan	en
local.contributor.firstname	Brian	en
local.contributor.firstname	Cian	en
local.contributor.firstname	Ciara	en
local.contributor.firstname	Jacintha	en
local.contributor.firstname	David	en
local.profile.school	School of Health	en
local.profile.email	abuckl23@une.edu.au	en
local.output.category	C1	en
local.record.place	au	en
local.record.institution	University of New England	en
local.publisher.place	Korea, Republic of	en
local.format.startpage	381	en
local.format.endpage	385	en
local.peerreviewed	Yes	en
local.identifier.volume	20	en
local.identifier.issue	3	en
local.access.fulltext	Yes	en
local.contributor.lastname	O’Connell	en
local.contributor.lastname	Doherty	en
local.contributor.lastname	Buckley	en
local.contributor.lastname	Cormican	en
local.contributor.lastname	Dunne	en
local.contributor.lastname	Hartery	en
local.contributor.lastname	Larkin	en
local.contributor.lastname	MacCarthy	en
local.contributor.lastname	McCormick	en
local.contributor.lastname	McKiernan	en
local.contributor.lastname	Mehigan	en
local.contributor.lastname	Muldoon	en
local.contributor.lastname	Ryan	en
local.contributor.lastname	O’Sullivan	en
local.contributor.lastname	Kevans	en
dc.identifier.staff	une-id:abuckl23	en
local.profile.orcid	0000-0002-5080-8580	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.profile.role	author	en
local.identifier.unepublicationid	une:1959.11/61207	en
local.date.onlineversion	2022	-
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
dc.identifier.academiclevel	Academic	en
local.title.maintitle	Colonic oncostatin M expression evaluated by immunohistochemistry and infliximab therapy outcome in corticosteroid-refractory acute severe ulcerative colitis	en
local.output.categorydescription	C1 Refereed Article in a Scholarly Journal	en
local.search.author	O’Connell, Jim	en
local.search.author	Doherty, Jayne	en
local.search.author	Buckley, Amy	en
local.search.author	Cormican, David	en
local.search.author	Dunne, Cara	en
local.search.author	Hartery, Karen	en
local.search.author	Larkin, John	en
local.search.author	MacCarthy, Finbar	en
local.search.author	McCormick, Paul	en
local.search.author	McKiernan, Susan	en
local.search.author	Mehigan, Brian	en
local.search.author	Muldoon, Cian	en
local.search.author	Ryan, Ciara	en
local.search.author	O’Sullivan, Jacintha	en
local.open.fileurl	https://rune.une.edu.au/web/retrieve/5db9239c-8b09-49ae-8d29-6dab5af655ac	en
local.uneassociation	No	en
local.atsiresearch	No	en
local.sensitive.cultural	No	en
local.year.available	2022	en
local.year.published	2022	en
local.fileurl.open	https://rune.une.edu.au/web/retrieve/5db9239c-8b09-49ae-8d29-6dab5af655ac	en
local.fileurl.openpublished	https://rune.une.edu.au/web/retrieve/5db9239c-8b09-49ae-8d29-6dab5af655ac	en
local.subject.for2020	3211 Oncology and carcinogenesis	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	External Affiliation	en
local.profile.affiliationtype	Unknown	en
Appears in Collections:	Journal Article School of Health

Files in This Item:

2 files

File	Description	Size	Format
openpublished/ColonicBuckley2022JournalArticle.pdf	Published version	1.07 MB	Adobe PDF Download Adobe	View/Open

Show simple item record

SCOPUS^TM
Citations

1

checked on Jan 4, 2025

Page view(s)

186

checked on Aug 3, 2024

Download(s)

8

checked on Aug 3, 2024

Google Scholar^TM

Check

Altmetric

This item is licensed under a Creative Commons License

Research UNE