Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/6109
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dc.contributor.authorHauptli, Sandien
dc.contributor.authorColegate, Stevenen
dc.contributor.authorGlover, Stephenen
dc.contributor.authorMcClure, Susanen
local.source.editorEditor(s): Kip E. Panter, Terrie L. Wierenga, James A. Pfister.en
dc.date.accessioned2010-06-02T09:27:00Z-
dc.date.issued2007-
dc.identifier.citationPoisonous Plants: Global Research and Solutions, p. 242-247en
dc.identifier.isbn9781845932732en
dc.identifier.isbn1845932730en
dc.identifier.urihttps://hdl.handle.net/1959.11/6109-
dc.description.abstractAnnual ryegrass toxicity (ARGD is a neurological disease of livestock that is caused by corynetoxins (Cfs) and results in major economic losses to the Australian livestock industry annually. The commercially available tunicamycins (TMs) are structurally, biochemically and toxicologically very similar to the corynctoxins (Edgar et al. 1982; Vogel et al. 1982; lago et al. 1983; Frahn et al. 1984) and have been used to model ARGT due to the intrinsic difficulties in isolating large amounts of pure corynetoxins. MGT has been produced experimentally in sheep following oral dosing of infected ryegrass and by subcutaneous injection of tlmicamycins (Berry et al. 1982; Finnic and Jago 1985). In preparation for assessing the protective effect of mucosal vaccination for ARGT, it was necessary to delemline the dose-response relationship, especially that of the liver, of lunieamycins surgically administered into the duodenum of sheep as a model for the natural route of exposure to the toxins. The aim of this study was to determine the minimum single, intra-duodenal dose of tunicamycins that would significantly alter serum biochemistry (liver enzymes, albumin, total protein and total bilirubin) but would not induce overt clinical signs of the disease. This dose would subsequently be used as a challenge dose in the mucosal vaccination experiments.en
dc.languageenen
dc.publisherCABIen
dc.relation.ispartofPoisonous Plants: Global Research and Solutionsen
dc.relation.isversionof1en
dc.titleDose Response of Tunicamycins in Sheep Following Intra-duodenal Administrationen
dc.typeBook Chapteren
dc.subject.keywordsAnimal Protection (Pests and Pathogens)en
dc.subject.keywordsAnimal Nutritionen
dc.subject.keywordsVeterinary Immunologyen
local.contributor.firstnameSandien
local.contributor.firstnameStevenen
local.contributor.firstnameStephenen
local.contributor.firstnameSusanen
local.subject.for2008070205 Animal Protection (Pests and Pathogens)en
local.subject.for2008070204 Animal Nutritionen
local.subject.for2008070705 Veterinary Immunologyen
local.subject.seo2008830310 Sheep - Meaten
local.identifier.epublicationsvtls086518651en
local.profile.schoolChemistryen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolChemistryen
local.profile.emailsmaxwel3@une.edu.auen
local.profile.emailsglover@une.edu.auen
local.output.categoryB1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20100510-114524en
local.publisher.placeWallingford, United Kingdomen
local.identifier.totalchapters93en
local.format.startpage242en
local.format.endpage247en
local.contributor.lastnameHauptlien
local.contributor.lastnameColegateen
local.contributor.lastnameGloveren
local.contributor.lastnameMcClureen
dc.identifier.staffune-id:smaxwel3en
dc.identifier.staffune-id:sgloveren
local.profile.orcid0000-0002-9344-8669en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:6265en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleDose Response of Tunicamycins in Sheep Following Intra-duodenal Administrationen
local.output.categorydescriptionB1 Chapter in a Scholarly Booken
local.relation.urlhttp://books.google.co.uk/books?id=IGjGQgAACAAJ&dq=9781845932732&cd=1en
local.relation.urlhttp://bookshop.cabi.org/?page=2633&pid=2047&site=191en
local.relation.urlhttp://trove.nla.gov.au/work/26049148?selectedversion=NBD41249314en
local.search.authorHauptli, Sandien
local.search.authorColegate, Stevenen
local.search.authorGlover, Stephenen
local.search.authorMcClure, Susanen
local.uneassociationUnknownen
local.isrevisionNoen
local.year.published2007en
Appears in Collections:Book Chapter
School of Science and Technology
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