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https://hdl.handle.net/1959.11/52188
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DC Field | Value | Language |
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dc.contributor.author | Borén, Jan | en |
dc.contributor.author | Watts, Gerald F | en |
dc.contributor.author | Adiels, Martin | en |
dc.contributor.author | Söderlund, Sanni | en |
dc.contributor.author | Chan, Dick C | en |
dc.contributor.author | Hakkarainen, Antti | en |
dc.contributor.author | Lundbom, Jesper | en |
dc.contributor.author | Lundbom, Nina | en |
dc.contributor.author | Matikainen, Niina | en |
dc.contributor.author | Kahri, Juhani | en |
dc.contributor.author | Vergès, Bruno | en |
dc.contributor.author | Barrett, P Hugh R | en |
dc.contributor.author | Taskinen, Marja-Riitta | en |
dc.date.accessioned | 2022-05-17T04:44:02Z | - |
dc.date.available | 2022-05-17T04:44:02Z | - |
dc.date.issued | 2015-10 | - |
dc.identifier.citation | Arteriosclerosis, Thrombosis, and Vascular Biology, 35(10), p. 2218-2224 | en |
dc.identifier.issn | 1524-4636 | en |
dc.identifier.issn | 1079-5642 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/52188 | - |
dc.description.abstract | <p><i><b>Objectives</b></i> - Patients with obesity and diabetes mellitus have increased risk of cardiovascular disease. A major cause is an atherogenic dyslipidemia related primarily to elevated plasma concentrations of triglyceride-rich lipoproteins. The aim of this study was to clarify determinants of plasma triglyceride concentration. We focused on factors that predict the kinetics of very-low density lipoprotein 1 (VLDL<sub>1</sub>) triglycerides.<br/> <i><b>Approach and Results</b></i> - A multicenter study using dual stable isotopes (deuterated leucine and glycerol) and multicompartmental modeling was performed to elucidate the kinetics of triglycerides and apoB in VLDL<sub>1</sub> in 46 subjects with abdominal obesity and additional cardiometabolic risk factors. Results showed that plasma triglyceride concentrations were dependent on both the secretion rate (<i>r</i>=0.44, <i>P</i><0.01; <i>r</i>=0.45, <i>P</i><0.01) and fractional catabolism (<i>r</i>=0.49, <i>P</i><0.001;<i> r</i>=0.55, <i>P</i><0.001) of VLDL<sub>1</sub>-triglycerides and VLDL<sub>1</sub>-apoB. Liver fat mass was independently and directly associated with secretion rates of VLDL<sub>1</sub>-triglycerides (<i>r</i>=0.56, <i>P</i><0.001) and VLDL<sub>1</sub>-apoB (<i>r</i>=0.53, <i>P</i><0.001). Plasma apoC-III concentration was independently and inversely associated with the fractional catabolisms of VLDL<sub>1</sub>-triglycerides (<i>r</i>=0.48, <i>P</i><0.001) and VLDL<sub>1</sub>-apoB (<i>r</i>=0.51, <i>P</i><0.001).<br/> <i><b>Conclusions</b></i> - Plasma triglyceride concentrations in abdominal obesity are determined by the kinetics of VLDL<sub>1</sub> subspecies, catabolism being mainly dependent on apoC-III concentration and secretion on liver fat content. Reduction in liver fat and targeting apoC-III may be an effective approach for correcting triglyceride metabolism atherogenic dyslipidemia in obesity.</p> | en |
dc.language | en | en |
dc.publisher | Lippincott Williams & Wilkins | en |
dc.relation.ispartof | Arteriosclerosis, Thrombosis, and Vascular Biology | en |
dc.title | Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity: Multicenter Tracer Kinetic Study | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1161/ATVBAHA.115.305614 | en |
dc.identifier.pmid | 26315407 | en |
dcterms.accessRights | Bronze | en |
local.contributor.firstname | Jan | en |
local.contributor.firstname | Gerald F | en |
local.contributor.firstname | Martin | en |
local.contributor.firstname | Sanni | en |
local.contributor.firstname | Dick C | en |
local.contributor.firstname | Antti | en |
local.contributor.firstname | Jesper | en |
local.contributor.firstname | Nina | en |
local.contributor.firstname | Niina | en |
local.contributor.firstname | Juhani | en |
local.contributor.firstname | Bruno | en |
local.contributor.firstname | P Hugh R | en |
local.contributor.firstname | Marja-Riitta | en |
local.relation.isfundedby | NHMRC | en |
local.profile.school | Faculty of Medicine and Health | en |
local.profile.email | pbarret6@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United States of America | en |
local.format.startpage | 2218 | en |
local.format.endpage | 2224 | en |
local.identifier.scopusid | 84942246192 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 35 | en |
local.identifier.issue | 10 | en |
local.title.subtitle | Multicenter Tracer Kinetic Study | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Borén | en |
local.contributor.lastname | Watts | en |
local.contributor.lastname | Adiels | en |
local.contributor.lastname | Söderlund | en |
local.contributor.lastname | Chan | en |
local.contributor.lastname | Hakkarainen | en |
local.contributor.lastname | Lundbom | en |
local.contributor.lastname | Lundbom | en |
local.contributor.lastname | Matikainen | en |
local.contributor.lastname | Kahri | en |
local.contributor.lastname | Vergès | en |
local.contributor.lastname | Barrett | en |
local.contributor.lastname | Taskinen | en |
dc.identifier.staff | une-id:pbarret6 | en |
local.profile.orcid | 0000-0003-3223-6125 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/52188 | en |
local.date.onlineversion | 2015-08-27 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity | en |
local.relation.fundingsourcenote | This work was supported by grants from Helsinki University Central Hospital EVO (Finnish State Grant) funds, Finnish Diabetes Research Foundation, Sigrid Juselius Foundation, Swedish Research Council, Swedish Heart-Lung Foundation, Diabetes Research Wellness Foundation, Novo Nordisk Foundation, Swedish Diabetes Foundation, Sahlgrenska University Hospital ALF funds, Sanofi, and by the National Health and Medical Research Council. | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.relation.doi | 10.1161/ATV.0000000000000026 | en |
local.search.author | Borén, Jan | en |
local.search.author | Watts, Gerald F | en |
local.search.author | Adiels, Martin | en |
local.search.author | Söderlund, Sanni | en |
local.search.author | Chan, Dick C | en |
local.search.author | Hakkarainen, Antti | en |
local.search.author | Lundbom, Jesper | en |
local.search.author | Lundbom, Nina | en |
local.search.author | Matikainen, Niina | en |
local.search.author | Kahri, Juhani | en |
local.search.author | Vergès, Bruno | en |
local.search.author | Barrett, P Hugh R | en |
local.search.author | Taskinen, Marja-Riitta | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.identifier.wosid | 000361610700018 | en |
local.year.available | 2015 | en |
local.year.published | 2015 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/60e8cba7-6be6-4dc6-a710-9d400efdb87e | en |
local.subject.for2020 | 320101 Cardiology (incl. cardiovascular diseases) | en |
local.subject.seo2020 | 200105 Treatment of human diseases and conditions | en |
Appears in Collections: | Journal Article |
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