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https://hdl.handle.net/1959.11/49238
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hodson, Leanne | en |
dc.contributor.author | Banerjee, Rajahshi | en |
dc.contributor.author | Rial, Belén | en |
dc.contributor.author | Arlt, Wiebke | en |
dc.contributor.author | Adiels, Martin | en |
dc.contributor.author | Boren, Jan | en |
dc.contributor.author | Marinou, Kyriakoula | en |
dc.contributor.author | Fisher, Ciaran | en |
dc.contributor.author | Mostad, Ingrid L | en |
dc.contributor.author | Stratton, Irene M | en |
dc.contributor.author | Barrett, P Hugh R | en |
dc.contributor.author | Chan, Dick C | en |
dc.contributor.author | Watts, Gerald F | en |
dc.contributor.author | Harnden, Karin | en |
dc.contributor.author | Karpe, Fredrik | en |
dc.contributor.author | Fielding, Barbara A | en |
dc.date.accessioned | 2022-03-14T00:05:51Z | - |
dc.date.available | 2022-03-14T00:05:51Z | - |
dc.date.issued | 2015-10-27 | - |
dc.identifier.citation | Journal of the American Heart Association, 4(10), p. 1-14 | en |
dc.identifier.issn | 2047-9980 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/49238 | - |
dc.description.abstract | Background Android fat distribution (abdominal obesity) is associated with insulin resistance, hepatic steatosis, and greater secretion of large very low‐density lipoprotein (VLDL) particles in men. Since abdominal obesity is becoming increasingly prevalent in women, we aimed to investigate the relationship between android fat and hepatic lipid metabolism in pre‐ and postmenopausal women. Methods and Results We used a combination of stable isotope tracer techniques to investigate intrahepatic fatty acid synthesis and partitioning in 29 lean and 29 abdominally obese women (android fat/total fat 0.065 [0.02 to 0.08] and 0.095 [0.08 to 0.11], respectively). Thirty women were premenopausal aged 35 to 45 and they were matched for abdominal obesity with 28 postmenopausal women aged 55 to 65. As anticipated, abdominal obese women were more insulin resistant with enhanced hepatic secretion of large (404±30 versus 268±26 mg/kg lean mass, P<0.001) but not small VLDL (160±11 versus 142±13). However, postmenopausal status had a pronounced effect on the characteristics of small VLDL particles, which were considerably triglyceride‐enriched (production ratio of VLDL2‐ triglyceride:apolipoprotein B 30±5.3 versus 19±1.6, P<0.05). In contrast to postmenopausal women, there was a tight control of hepatic fatty acid metabolism and triglyceride production in premenopausal women, whereby oxidation (rs=−0.49, P=0.006), de novo lipogenesis (rs=0.55, P=0.003), and desaturation (rs=0.48, P=0.012) were closely correlated with abdominal obesity‐driven large VLDL‐triglyceride secretion rate. Conclusions In women, abdominal obesity is a major driver of hepatic large VLDL particle secretion, whereas postmenopausal status was characterized by increased small VLDL particle size. These data provide a mechanistic basis for the hyperlipidemia observed in postmenopausal obesity. | en |
dc.language | en | en |
dc.publisher | Wiley-Blackwell Publishing, Inc | en |
dc.relation.ispartof | Journal of the American Heart Association | en |
dc.rights | Attribution-NonCommercial 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.title | Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1161/JAHA.115.002258 | en |
dcterms.accessRights | UNE Green | en |
local.contributor.firstname | Leanne | en |
local.contributor.firstname | Rajahshi | en |
local.contributor.firstname | Belén | en |
local.contributor.firstname | Wiebke | en |
local.contributor.firstname | Martin | en |
local.contributor.firstname | Jan | en |
local.contributor.firstname | Kyriakoula | en |
local.contributor.firstname | Ciaran | en |
local.contributor.firstname | Ingrid L | en |
local.contributor.firstname | Irene M | en |
local.contributor.firstname | P Hugh R | en |
local.contributor.firstname | Dick C | en |
local.contributor.firstname | Gerald F | en |
local.contributor.firstname | Karin | en |
local.contributor.firstname | Fredrik | en |
local.contributor.firstname | Barbara A | en |
local.relation.isfundedby | NHMRC | en |
local.profile.school | Faculty of Medicine and Health | en |
local.profile.email | pbarret6@une.edu.au | en |
local.output.category | C1 | en |
local.grant.number | G 11P 5739 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United States of America | en |
local.identifier.runningnumber | e002258 | en |
local.format.startpage | 1 | en |
local.format.endpage | 14 | en |
local.identifier.scopusid | 85006223091 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 4 | en |
local.identifier.issue | 10 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Hodson | en |
local.contributor.lastname | Banerjee | en |
local.contributor.lastname | Rial | en |
local.contributor.lastname | Arlt | en |
local.contributor.lastname | Adiels | en |
local.contributor.lastname | Boren | en |
local.contributor.lastname | Marinou | en |
local.contributor.lastname | Fisher | en |
local.contributor.lastname | Mostad | en |
local.contributor.lastname | Stratton | en |
local.contributor.lastname | Barrett | en |
local.contributor.lastname | Chan | en |
local.contributor.lastname | Watts | en |
local.contributor.lastname | Harnden | en |
local.contributor.lastname | Karpe | en |
local.contributor.lastname | Fielding | en |
dc.identifier.staff | une-id:pbarret6 | en |
local.profile.orcid | 0000-0003-3223-6125 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/49238 | en |
local.date.onlineversion | 2015-10-02 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women | en |
local.relation.fundingsourcenote | The study was funded by the British Heart Foundation (Project Grant PG/09/003) and Hodson is a British Heart Foundation Intermediate Fellow in Basic Science (FS/11/18/28633). The British Heart Foundation had no role in the design, analysis, or writing of this article. Marinou was funded by the European Commission under the Marie Curie Programme (FP7-PEOPLE-2011-IEF). The contents reflect only the author’s views and not the views of the European Commission. ApoC-III kinetics were funded by a grant from the National Heart Foundation of Australia (G 11P 5739). PHRB is a senior research fellow of the National Health and Medical Research Council (NHMRC) of Australia. Chan is a career development fellow of the NHMRC | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.relation.grantdescription | NHMRC/G 11P 5739 | en |
local.search.author | Hodson, Leanne | en |
local.search.author | Banerjee, Rajahshi | en |
local.search.author | Rial, Belén | en |
local.search.author | Arlt, Wiebke | en |
local.search.author | Adiels, Martin | en |
local.search.author | Boren, Jan | en |
local.search.author | Marinou, Kyriakoula | en |
local.search.author | Fisher, Ciaran | en |
local.search.author | Mostad, Ingrid L | en |
local.search.author | Stratton, Irene M | en |
local.search.author | Barrett, P Hugh R | en |
local.search.author | Chan, Dick C | en |
local.search.author | Watts, Gerald F | en |
local.search.author | Harnden, Karin | en |
local.search.author | Karpe, Fredrik | en |
local.search.author | Fielding, Barbara A | en |
local.open.fileurl | https://rune.une.edu.au/web/retrieve/3d65950b-a385-4424-a5ba-7a223db0161b | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.year.available | 2015 | en |
local.year.published | 2015 | en |
local.fileurl.open | https://rune.une.edu.au/web/retrieve/3d65950b-a385-4424-a5ba-7a223db0161b | en |
local.fileurl.openpublished | https://rune.une.edu.au/web/retrieve/3d65950b-a385-4424-a5ba-7a223db0161b | en |
local.subject.for2020 | 320101 Cardiology (incl. cardiovascular diseases) | en |
local.subject.seo2020 | 200105 Treatment of human diseases and conditions | en |
Appears in Collections: | Journal Article |
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openpublished/MenopausalBarrett2015JournalArticle.pdf | Published version | 626.59 kB | Adobe PDF Download Adobe | View/Open |
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