| Title: | ApoA-II HDL catabolism and its relationships with the kinetics of ApoA-I HDL and of VLDL1, in abdominal obesity |
Contributor(s): | Vergès, Bruno (author); Adiels, Martin (author); Boren, Jan (author); Barrett, Peter Hugh (author) ; Watts, Gerald F (author); Chan, Dick (author); Duvillard, Laurence (author); Söderlund, Sanni (author); Matikainen, Niina (author); Kahri, Juhani (author); Lundbom, Nina (author); Lundbom, Jesper (author); Hakkarainen, Antti (author); Aho, Serge (author); Simoneau-Robin, Isabelle (author); Taskinen, Marja-Riitta (author) |
Publication Date: | 2016-04-01 |
Early Online Version: | 2016-02-02 |
DOI: | 10.1210/jc.2015-3740 |
Handle Link: | https://hdl.handle.net/1959.11/48380 |
Abstract: | | Context:
The metabolism of high-density lipoprotein (HDL) is severely impaired in individuals with abdominal obesity. However, the specific metabolism of apolipoprotein (apo)-A-II, the second major apolipoprotein of HDL, remains poorly known. The relationships between HDL apoA-II catabolism and other metabolic variables that may be modified in abdominal obesity, such as very low-density lipoprotein (VLDL) subspecies (VLDL1, VLDL2) kinetics, remain to be investigated.
Objectives:
Our aim was to study the associations between apoA-II fractional catabolic rate (FCR) and the kinetics of VLDL subspecies and apoA-I.
Design:
We carried out a multicenter in vivo kinetic study using stable isotopes (deuterated leucine and glycerol) in 62 individuals with abdominal obesity.
Results:
In a univariate analysis, apoA-II FCR was positively correlated with body mass index, sc fat, liver fat, apoA-I FCR, apoA-I production rate (PR), apoA-II pool, apoA-II PR, VLDL1-triglyceride PR, VLDL2-triglyceride PR, VLDL2-triglyceride (TG) FCR, and VLDL2-apoB FCR and negatively with HDL cholesterol to apoA-I ratio. After adjustment for apoA-I FCR, a strong positive correlation between apoA-II FCR and VLDL1-TG indirect FCR was observed (r = 0.520, P < .0001). In a multivariate analysis, apoA-II FCR was independently and positively associated with apoA-I FCR (P < .0001) and VLDL1-TG indirect FCR (P < .0001). Both variables explained 59.7% of the variability in apoA-II FCR.
Conclusions:
We show that, in abdominally obese individuals, apoA-II FCR is positively and independently associated with both apoA-I FCR and VLDL1-TG indirect FCR. These data suggest that, in a condition of delayed VLDL1 catabolism, such as abdominal obesity, retention of apoA-II in the VLDL1 pool may occur, with an effect on apoA-II catabolism. The consequences of this link between VLDL1 catabolism and apoA-II catabolism remain to be determined.
Publication Type: | Journal Article |
Source of Publication: | Journal of Clinical Endocrinology and Metabolism, 101(4), p. 1398-1406 |
Publisher: | Oxford University Press |
Place of Publication: | United States of America |
ISSN: | 1945-7197
0021-972X |
Fields of Research (FoR) 2020: | 320101 Cardiology (incl. cardiovascular diseases) |
Socio-Economic Objective (SEO) 2020: | 200105 Treatment of human diseases and conditions |
Peer Reviewed: | Yes |
HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
| Appears in Collections: | Journal Article
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