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https://hdl.handle.net/1959.11/48116
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DC Field | Value | Language |
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dc.contributor.author | Hooper, Amanda J | en |
dc.contributor.author | Robertson, Ken | en |
dc.contributor.author | Champain, Danie | en |
dc.contributor.author | Hua, Jianmin | en |
dc.contributor.author | Song, Swithin | en |
dc.contributor.author | Parhofer, Klaus G | en |
dc.contributor.author | Barrett, P Hugh R | en |
dc.contributor.author | van Bockxmeer, Frank M | en |
dc.contributor.author | Burnett, John R | en |
dc.date.accessioned | 2022-03-09T20:41:08Z | - |
dc.date.available | 2022-03-09T20:41:08Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.citation | Clinical Biochemistry, 49(9), p. 720-722 | en |
dc.identifier.issn | 1873-2933 | en |
dc.identifier.issn | 0009-9120 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/48116 | - |
dc.description.abstract | <p>Objective</p> <p>Familial hypobetalipoproteinemia (FHBL) is characterized by mutations in APOB, the majority of these causing protein truncations, and low plasma levels of apolipoprotein (apo) B. The hypobetalipoproteinemia may be due to enhanced clearance and possibly reduced production of apoB-containing lipoproteins; the mechanism may depend on the length of the apoB truncation. We studied fasting lipoprotein metabolism in an FHBL subject heterozygous for a mutation causing a truncated apoB, apoB-80.</p> <p>Design and Methods</p> <p>Very low density lipoprotein (VLDL)-, intermediate density lipoprotein (IDL)-, and low density lipoprotein (LDL)-apoB kinetics were determined in the fasting state using stable isotope methods and compartmental modeling.</p> <p>Results</p> <p>Compared with lean normolipidemic controls the apoB-80 FHBL subject had an elevated VLDL-apoB fractional catabolic rate and lower LDL production. ApoB production rates and IDL- and LDL-apoB fractional catabolic rates were not different.</p> <p>Conclusion</p> <p>FHBL subjects heterozygous for a mutation truncating apoB to 80% of full-length are able to produce VLDL-apoB normally, but have rapid clearance of these particles, resulting in low levels of circulating apoB.</p> | en |
dc.language | en | en |
dc.publisher | Elsevier Inc | en |
dc.relation.ispartof | Clinical Biochemistry | en |
dc.title | Lipoprotein metabolism in an apoB-80 familial hypobetalipoproteinemia heterozygote | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1016/j.clinbiochem.2016.02.008 | en |
dc.identifier.pmid | 26916057 | en |
local.contributor.firstname | Amanda J | en |
local.contributor.firstname | Ken | en |
local.contributor.firstname | Danie | en |
local.contributor.firstname | Jianmin | en |
local.contributor.firstname | Swithin | en |
local.contributor.firstname | Klaus G | en |
local.contributor.firstname | P Hugh R | en |
local.contributor.firstname | Frank M | en |
local.contributor.firstname | John R | en |
local.relation.isfundedby | NHMRC | en |
local.profile.school | Faculty of Medicine and Health | en |
local.profile.email | pbarret6@une.edu.au | en |
local.output.category | C1 | en |
local.grant.number | 1010133 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United States of America | en |
local.format.startpage | 720 | en |
local.format.endpage | 722 | en |
local.identifier.scopusid | 84959441035 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 49 | en |
local.identifier.issue | 9 | en |
local.contributor.lastname | Hooper | en |
local.contributor.lastname | Robertson | en |
local.contributor.lastname | Champain | en |
local.contributor.lastname | Hua | en |
local.contributor.lastname | Song | en |
local.contributor.lastname | Parhofer | en |
local.contributor.lastname | Barrett | en |
local.contributor.lastname | van Bockxmeer | en |
local.contributor.lastname | Burnett | en |
dc.identifier.staff | une-id:pbarret6 | en |
local.profile.orcid | 0000-0003-3223-6125 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/48116 | en |
local.date.onlineversion | 2016-02-23 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Lipoprotein metabolism in an apoB-80 familial hypobetalipoproteinemia heterozygote | en |
local.relation.fundingsourcenote | Practitioner Fellowship from the Royal Perth Hospital Medical Research Foundation (to JRB) and PHRB is a NHMRC Senior Research Fellow. | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.relation.grantdescription | NHMRC/1010133 | en |
local.search.author | Hooper, Amanda J | en |
local.search.author | Robertson, Ken | en |
local.search.author | Champain, Danie | en |
local.search.author | Hua, Jianmin | en |
local.search.author | Song, Swithin | en |
local.search.author | Parhofer, Klaus G | en |
local.search.author | Barrett, P Hugh R | en |
local.search.author | van Bockxmeer, Frank M | en |
local.search.author | Burnett, John R | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.identifier.wosid | 000377030600014 | en |
local.year.available | 2016 | en |
local.year.published | 2016 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/64389178-96bc-48bc-a5df-8ec0e9a85d16 | en |
local.subject.for2020 | 320101 Cardiology (incl. cardiovascular diseases) | en |
local.subject.seo2020 | 200105 Treatment of human diseases and conditions | en |
Appears in Collections: | Journal Article |
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